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Automated Protein Structure Determination: NOAH/DIAMOD Method

Automated approach for determining protein structures revolutionizes research. Pioneering studies of proteins like Crambin, Neuron Toxin, Chemokine, and Attractin showcase the power of NOAH/DIAMOD method. These innovative techniques aid in unraveling molecular mysteries effectively and efficiently.

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Automated Protein Structure Determination: NOAH/DIAMOD Method

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  1. Protein Structures Determined by Our Automated Methods (NOAH/DIAMOD) 1) Crambin (48 residues, 2D NOESY) The first structure ever determined by automated approach) Xu, Y., Wu, J., Gorenstein, D. and Braun, W. J. Magnetic Resonance136, 76-85(1999) 2) Neuron Toxin (CsE5, 65 residues) 2D NOESY (H2O, D2O and jump-return) Xu, Y., Jablonsky, M. J., Jackson, P. L., Braun, W. and Krishna, N. R. J . Magnetic Resonance148, 35-46(2001) 3) Chemokine (Mpif, 77 residues) 2D NOESY, 3D 15N, and 13C edited SHQC NOESY Oezguen, N., Adamian, L., Xu, Y., Rajarathnam and Braun, W. J. Bimolecular NMR, 22, 249-263 (2002) 4) Attractin (58 residues, 2D NOESY) Garimella, R., Xu, Y., Schein, ,H., Rajarathnam, K., Nagle, G., Painter, S., and Braun, W. Biochemistry, 42(33):9970-9979, 2003 Supported by National Science Foundation (PI: W. Braun)

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