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Understanding Cellular Movement: The Dynamics of Cytoskeletal Motor Proteins

Explore how cytoskeletal motor proteins create motion inside cells, their importance in biology, and relevance to medicine. Learn about the components of molecular machines, such as microtubule and actin tracks, and motor proteins like kinesins, dyneins, and myosins. Discover the activities involving these proteins and how they contribute to organelle movement, mitotic spindle formation, and more.

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Understanding Cellular Movement: The Dynamics of Cytoskeletal Motor Proteins

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  1. Session I – How things move inside a cell 2/7/14 List different movements/motion that occur inside an organism

  2. A typical highway road map

  3. Transport road map of a cell http://www.youtube.com/watch?v=wJyUtbn0O5Y

  4. Watch (Cell Biology) Measure and Quantify (Systems/Quantitative Biology, Physics) Disable (Geneticists) Analysis/Optimization ( Bio-engineering)

  5. An effort to understand how these cytoskeletal motor proteins works inside the cell?

  6. Why study cytoskeletal motor proteins? • To understand how living organisms create motion • Important in every facet of biology • Relevance to medicine

  7. Components of molecular machines – Cytoskeletal motors work on tracks Microtubule track Actin track Motor proteins – Kinesins, Dyneins Motor protein – Myosins

  8. Microtubules maintain “polarity”

  9. Location of the tracks inside the cell Microtubules (red) DNA ( blue) Actin filaments ( green)

  10. + end - end

  11. Kinesin Motor protein

  12. Kinesin functions- 45 human genes • Organelle movement (eg Golgi, ER) • Transport or localization • of RNA/proteins • Mitotic spindle formation • and chromosome formation • Ciliary biogenesis

  13. Activities - Explain/Teach concepts to your peers Group 1 – Kinesin walking models. Discuss in vitro experimental observations http://www.stanford.edu/group/blocklab/kinesin/kinesin.html Group 1 presents on 2/14/14 Group 2 – How the motor proteins (Kinesins and Dyneins) convert chemical energy to mechanical energy Vale review paper Group 3 - How to study and perturb microtubule dynamics in vivo? Discuss an assay system to visualize microtubule plus end growth with fluorescent labelingusing a particular model system Review your own literature Group 2 & 3 presents on 2/21/14

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