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Cell Injury and Adaptations: Mechanisms and Consequences

Explore the different types of cell injuries leading to adaptations such as hypertrophy, hyperplasia, atrophy, and metaplasia. Understand the causes and effects of cell injury, death, and adaptive responses in various tissues and organs.

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Cell Injury and Adaptations: Mechanisms and Consequences

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  1. Cell injury, Cell death and Adaptations ManarHajeer, MD, FRCPath University of Jordan , school of medicine

  2. Cells Tissues Organs Systems Organism

  3. Adaptations

  4. Adaptations

  5. Hypertrophy

  6. Pathologiccardiac muscle in hypertension and aortic stenosis

  7. Physiologicuterine smooth muscle in pregnancy

  8. Physiologicskeletal muscle in athletes

  9. Hyperplasia

  10. Physiologicbreast in pregnancy and lactation

  11. Pathologic endometrial hyperplasia, estrogen induced

  12. Atrophy

  13. Causes: • Decreased workload (immobilization of a limb after fracture) • Loss of innervations • Diminished blood supply, • Inadequate nutrition • Loss of endocrine stimulation • Aging (senile atrophy)

  14. Metaplasia

  15. Cell injury and death

  16. CAUSES OF CELL INJURY

  17. Oxygen Deprivation

  18. Chemical Agents

  19. Infectious Agents

  20. Immunologic Reactionsautoimmune, allergic, microbes

  21. Genetic Factors

  22. Nutritional Imbalances

  23. Physical Agents

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