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Cell injury p.2 and cell death

Cell injury p.2 and cell death

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Cell injury p.2 and cell death

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  1. Cell injury p.2 and cell death • SYLLABUS: • Robbins and Cotran, PathologicBasis of Disease, Chapter: • CellularResponses to Stress and ToxicInsults: Adaptation, Injury, and Death • excluding: • hypertrophy • hyperplasia • metaplasia

  2. Cell injury p.2 and cell death 28Kidney amyloidosis 39Caseous necrosis (tuberculosis, lymph node) 40Liquefactive necrosis (peptic ulcer) 43Balser necrosis (enzymatic fat necrosis) s/35Epidermal cyst 30Leukokeratosis (oral mucosa sample)

  3. Kidney amyloidosis -amyloid deposits in glomeruli and in the walls of blood vessels (metachromatic stain)

  4. Kidney amyloidosis

  5. Kidney amyloidosis

  6. Caseous necrosis (tuberculosis, lymph node) • area of necrosis: • amorphous, granular, pink debriswith no visible nuclei or cell contours • elements of TB granuloma: • giant Langhans cells • epithelioid cells • lymphocytes • lymph node structure

  7. Caseous necrosis (tuberculosis, lymph node)

  8. Caseous necrosis (tuberculosis, lymph node)

  9. Caseous necrosis (tuberculosis, lymph node)

  10. Liquefactive necrosis (peptic ulcer) • defect (excavation) caused by the necrosis of the previously pathologically altered tissue • -thin layer of necrotic tissue debris • -underlying inflammatory infiltration

  11. Liquefactive necrosis (peptic ulcer)

  12. Liquefactive necrosis (peptic ulcer)

  13. Balser necrosis (enzymatic fat necrosis) -shadowy outlines of necrotic fat cells -basophilic deposits replacing fat in cells -surrounding inflammatory infiltration

  14. Balser necrosis (enzymatic fat necrosis)

  15. Balser necrosis (enzymatic fat necrosis)

  16. Epidermal cyst -normotypical (sometimes flattened) squamous epithelium lining the cyst -keratin masses filling the cyst

  17. Epidermal cyst

  18. Epidermal cyst

  19. Leukokeratosis (oral mucosa sample) -keratinizing squamous epithelium (with granular and keratinized layer) (no skin appendages visible) (.ppt demonstration only, no slides during the microscopy lab)

  20. Leukokeratosis (oral mucosa sample)

  21. Leukokeratosis (oral mucosa sample)