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The Complex Relationship Between Stress and Memory: Enhancement vs. Impairment

This exploration examines the intricate ties between stress and memory. Stressful events can enhance memory consolidation through the release of stress hormones like cortisol and activation of the amygdala. However, prolonged exposure to stress can harm the brain, particularly the hippocampus, impairing memory function. Key neurobiological mechanisms, including CRH and CRHR receptors, reveal how acute stress affects memory storage. Importantly, memory impairments caused by stress are reversible through effective management of cortisol levels. Understanding this balance is crucial for mental health.

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The Complex Relationship Between Stress and Memory: Enhancement vs. Impairment

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  1. Does Stress Really Impair Memory? Student’s Name：顏嘉賢 School Number：B9802033

  2. QUESTION • How is stress related to memory? • Enhance? • Impair? • Why?

  3. INFORMATION 1: ENHANCEMENT OF MEMORY • Stressful / emotionally arousing events • enhance the “consolidation” of memory • Stress hormones • stress-activated neurotransmitters • Amygdala

  4. INFORMATION 2: STRESS HORMONES • Glucocorticoids • Cortisol • Stress cortisol receptor • Long-term exposure to cortisol atrophy of hippocampus naturally (In hippocampus)

  5. Dendritic Spine • Learning & memory • Synapses

  6. synapse

  7. INFORMATION 3: CRH &CRHR • CRH: corticotropin releasing hormone • Secreted by hypothalamus • CRHR: CRH receptor • Located in hippocampus

  8. “consolidation” Acute Stress CRH release hippocampus dendritic spines disintegration CRHR impair memory storage collection

  9. On the contrary… CRH CRHR BLOCK damage eliminated binding

  10. INFORAMTION 4: REVERSIBILITY • From Newcomer’s experiment: • Memory impairment is reversible • “the point of no return” • Controlling cortisol levels pharmacologically

  11. THE SAME QUESTION • How is stress related to memory? • Enhance? • Impair?

  12. THE ANSWER~~~~~ BOTH !!!! However…

  13. CONCLUSION • Stress itself is not harmful… but the EXCESS of stress is!!! • Acute or chronic exposure to stress causes functional and morphological alterations in the brain impair memory consolidation

  14. Thanks for your attention!

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