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Pennacchietti et al. Suppl. Fig. 3. MKN-45. H1993. MKN-45. H1993. DN30 Fab (nM). 0. 400. 0. 400. 0. 400. 0. 400. HGF (100 ng/ml). pAKT. pMET. AKT. MET. pHER3. ERK. HER3. HER3. pGAB1. GAB1. pERK.

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slide1

Pennacchietti et al. Suppl. Fig. 3

MKN-45

H1993

MKN-45

H1993

DN30 Fab (nM)

0

400

0

400

0

400

0

400

HGF (100 ng/ml)

pAKT

pMET

AKT

MET

pHER3

ERK

HER3

HER3

pGAB1

GAB1

pERK

Suppl. Fig. 3. HGF restores physiological, GAB-1-mediated MET signaling in DN30 Fab-treated MET-addicted cells. MKN-45 gastric carcinoma cells and H1993 lung carcinoma cells were incubated with the indicated concentrations of DN30 Fab in the absence or presence of 100 ng/ml HGF. Cell lysates were analyzed by Western blotting using antibodies directed against the indicated signaling proteins and their phosphorylated forms (indicated with the ‘p’ prefix).