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Effects of TGF-β2 and SD-208 on SMA-560 Cell Line: Supplementary Data Analysis

This document presents supplementary figures related to the analysis of the SMA-560 cell line's response to TGF-β2 and SD-208 treatments. The figures illustrate the influence of varying concentrations of GL-261 and Cil on the activation of pSmad2 and actin levels. Additional data include co-treatment effects, dose-response curves, and evidence of nuclear localization with NHS-Biotin. The findings provide insights into the signaling pathways affected by TGF-β2 in glioma cells and the potential mitigating effects of SD-208.

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Effects of TGF-β2 and SD-208 on SMA-560 Cell Line: Supplementary Data Analysis

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  1. Suppl. Fig. 1 GL-261 NS SMA-560 NS

  2. Suppl. Fig. 2 RAD GL-261 SMA-560 Cil Merge Merge NHS-Biotin NHS-Biotin Nucleus Nucleus

  3. Suppl. Fig. 3 A B

  4. Suppl. Fig. 4 SMA-560 SC RAD Cil Stauro

  5. Suppl. Fig. 5 GL-261 NS SMA-560 NS SMA-560 NS GL-261 NS 1 nM GLPG 1 nM GLPG 100 nM GLPG 100 nM GLPG 1 µM Cil 1 µM Cil 10 µM Cil 10 µM Cil RAD RAD DMSO DMSO pSmad2 pSmad2 actin actin

  6. Suppl. Fig. 6 A 0 ng/ml TGF-β2 0 ng/ml TGF-β2 0 ng/ml TGF-β2 0 ng/ml TGF-β2 0 ng/ml TGF-β2 + SD-208 0 ng/ml TGF-β2 + SD-208 0 ng/ml TGF-β2 + SD-208 0 ng/ml TGF-β2 + SD-208 0.1 ng/ml TGF-β2 0.1 ng/ml TGF-β2 0.1 ng/ml TGF-β2 0.1 ng/ml TGF-β2 0.1 ng/ml TGF-β2 + SD-208 0.1 ng/ml TGF-β2 + SD-208 0.1 ng/ml TGF-β2 + SD-208 0.1 ng/ml TGF-β2 + SD-208 1 ng/ml TGF-β2 1 ng/ml TGF-β2 1 ng/ml TGF-β2 1 ng/ml TGF-β2 1 ng/ml TGF-β2 + SD-208 1 ng/ml TGF-β2 + SD-208 1 ng/ml TGF-β2 + SD-208 1 ng/ml TGF-β2 + SD-208 B 10 ng/ml TGF-β2 10 ng/ml TGF-β2 10 ng/ml TGF-β2 10 ng/ml TGF-β2 10 ng/ml TGF-β2 + SD-208 10 ng/ml TGF-β2 + SD-208 10 ng/ml TGF-β2 + SD-208 10 ng/ml TGF-β2 + SD-208

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