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Assessment of KP46 Effects on Human Cancer Cells and Integrins in Tumor Growth

This study explores the impact of KP46 on apoptosis-related proteins in HCT-116, A549 cells over 15 hours. It also investigates KP46's influence on integrin b1 expression in A427, SW480 cells at varying timepoints. Results reveal potential therapeutic targets for cancer treatment.

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Assessment of KP46 Effects on Human Cancer Cells and Integrins in Tumor Growth

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  1. Jungwirth et al. Suppl. Fig. 1 A B

  2. Jungwirth et al. Suppl. Fig. 2 A HCT-116 A549 - + - + KP46 B Bax 4 hours15 hours Bim EL KP46 (µM) 0 2.5 10 2.5 10 C M C M C M C M C M C Bak Prohibitin b-actin Bcl-2 Bax GADPH

  3. Jungwirth et al. Suppl. Fig. 3 A B C HOS MG63 KP46 (µM) 0 10 0 10 Integrin b1 control KP46 b-actin DAPI F-actin DAPI F-actin A549 A427 SW480 Integrinb1 merged Integrinb1 merged time (hours) 0 3 6 0 3 6 0 3 6 Integrin b1 b-actin DAPI F-actin F-actin DAPI Talin merged merged Talin

  4. Jungwirth et al. Suppl. Fig. 4

  5. Jungwirth et al. Suppl. Fig. 5

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