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Understanding Purine Metabolism in Cellular Signaling Pathways

Explore the role of purines like ATP, AMP, and GTP in cellular signaling processes. Learn about key molecules like Adenine and Adenosine. Includes insights into different donor molecules and their impact on cellular functions.

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Understanding Purine Metabolism in Cellular Signaling Pathways

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  1. K6 K8 K5 (54.3) (49.5) (33.3) ATP AMP ADP GTP K20 K11 Purine dATP ddATP Adenine 8-Br-Ade Adenosine 3-Met-Ade No donor ATPγS only (11.4) (22.1) Fig. S2A ATP ATP AMP ADP AMP ADP GTP GTP dATP ddATP Purine dATP ddATP Adenine Purine 8-Br-Ade 8-Br-Ade Adenine Adenosine Adenosine 3-Met-Ade 3-Met-Ade No donor ATPγS only No donor ATPγS only

  2. Fig. S2B K22 K28 K37 (30.4) (55.1) (65.4) GTP GTP GTP ATP GDP GMP ITP GDP GMP ITP GDP GMP ITP ATP ATP dGTP Purine dGTP Purine dGTP Purine ddGTP ddGTP ddGTP No donor No donor No donor Guanosine Guanosine Guanosine 7-Met-GTP 7-Met-GTP 7-Met-GTP GTPγS only GTPγS only GTPγS only

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