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Cholera: Next Door?. BioQUEST 2012. Module Design. Case Study Format Learning Objectives Resources Data Analysis & Visualization Tools Statistics Assessment. Learning Objectives:. In this module, students will:

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cholera next door

Cholera: Next Door?

BioQUEST 2012

module design
Module Design
  • Case Study Format
    • Learning Objectives
    • Resources
  • Data Analysis & Visualization
    • Tools
    • Statistics
  • Assessment
learning objectives
Learning Objectives:
  • In this module, students will:
    • (1) investigate the natural history of Vibriocholerae, a pathogenic bacterium of global and historical significance. Use their knowledge of the organism’s biology to predict conditions favorable for epidemics.
    • (2) compare and contrast cholera outbreaks from multiple locations. Determine whether demographic, environmental, or other variables are associated with an epidemic’s magnitude of impact.
    • (3) model (or predict or explain) potential modes of disease transmission and/or dynamics of disease spread during an epidemic.
    • (4) improve foundational skills in:
      • searching and obtaining data available online;
      • evaluating quality of datasets from a variety of sources; and
      • interpreting, analyzing, and visualizing diverse types of data
online resources
Online Resources:

News & Media

  • http://www.catholic.org/international/international_story.php?id=44401&utm_source=catholic.org%2Fhomepage&utm_medium=banner&utm_content=latest%2Bnews - Catholic Online, posted 1/13/12
  • http://www.nytimes.com/2012/01/10/health/haitian-cholera-epidemic-traced-to-first-known-victim.html?_r=1&scp=1&sq=cholera%20haiti&st=cse - discovery of first cholera case in Haiti, NYT 1/10/12
  • http://www.npr.org/templates/story/story.php?storyId=144929218 - discovery of first cholera case in Haiti

Natural history, symptoms, epidemiology, general information

  • http://www.who.int/mediacentre/factsheets/fs107/en/index.html - WHO
  • http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001348/ - PubMed Health
  • http://www.cdc.gov/cholera/general/
  • http://www.cdc.gov/haiticholera/ - CDC
online resources1
Online Resources:

Accounts, reports of outbreaks

  • http://www.who.int/csr/don/archive/disease/cholera/en/index.html - periodic updates about outbreaks globally

Profiles of Countries with Cholera

  • http://www.who.int/cholera/countries/en/index.html - general information (geographic, economic, environmental) for countries with cholera in their histories

Data

  • http://apps.who.int/ghodata/?vid=2250 - cases, deaths, fatality rates by country, year
  • http://www.who.int/cholera/statistics/en/index.html - articles compiled annually with raw data
  • http://www.who.int/gho/epidemic_diseases/cholera/en/index.html - maps with data for cases, fatalities
  • http://emergency.cdc.gov/situationawareness/haiticholera/data.asp - stratified by region and demographics
online resources2
Online Resources:

Maps

  • http://gamapserver.who.int/mapLibrary/app/searchResults.aspx - WHO Cholera Map Library
  • http://emergency.cdc.gov/situationawareness/haiticholera/staticmaps.asp - multiple static maps (distribution of outbreaks, cumulative attack rates, etc)
  • http://gamapserver.who.int/gho/interactive_charts/cholera/atlas.html - interactive http://new.paho.org/hq/images/Atlas_IHR/CholeraHispaniola/atlas.html - interactive
  • http://www.bt.cdc.gov/situationawareness/haiticholera/Flash/bt/atlas.html - interactive, multiple filters and resolutions
slide7

http://books.google.com/books?id=LIYaAAAAMAAJ&lpg=PA173&ots=3A_xyGSTMb&dq=Cholera%20epidemic%20map%20of%20Nashville%2C%20Tennessee%2C%201873%20%2F%20Ely%20McClellan.&pg=PP11#v=onepage&q&f=truehttp://books.google.com/books?id=LIYaAAAAMAAJ&lpg=PA173&ots=3A_xyGSTMb&dq=Cholera%20epidemic%20map%20of%20Nashville%2C%20Tennessee%2C%201873%20%2F%20Ely%20McClellan.&pg=PP11#v=onepage&q&f=true

slide8

Cholera epidemic map of Nashville, Tennessee, 1873 / Ely McClellan.

http://www.nlm.nih.gov/exhibition/cholera/images/a024226.jpg

slide11

http://www.worldmapper.org/posters/worldmapper_map231_ver5.pdfhttp://www.worldmapper.org/posters/worldmapper_map231_ver5.pdf

pam american health organization interactive map
Pam American Health OrganizationInteractive map
  • http://new.paho.org/hq/images/Atlas_IHR/CholeraHispaniola/atlas.html
statistical analysis
Statistical Analysis
  • 1) Finding the “RIGHT” parameters
  • a) Sanitation
  • b) Population Density
  • c) Environmental Conditions
  • d) Non availability of Clean water
  • e) Limited Access to health care
  • f) General Awareness of disease spread
  • etc……..
crunching the data
Crunching the Data
  • Approach
  • 1) Undergraduate Level
  • a) Study the data set
  • b) Descriptive statistics
  • c) Plot the data
  • d) Use Regression Approach
  • e) Find the optimal model
  • f) Run the model diagnostics
crunching the data1
Crunching the Data
  • Approach
  • 2) Graduate Level
  • a) All above
  • b) Non-normal distribution
  • c) Poisson Modeling
  • c) MLE approach
  • d) Bayesian Model
  • e) Find the optimal model
  • f) Run the model diagnostics
assessment
Assessment
  • Pre/Post-Test Assessment
    • Learning & Thinking Skills
      • Presentations, Activities, Group Work
    • Science Process Skills
      • Solving problems, critical thinking, testing hypothesis
    • Attitudes Toward Science
      • Comfort & confidence
    • Module Content
      • Background info, mode of action & transmission, data analysis tools