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Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen

Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen Advisor: Andreas A. Linninger Presented on January 28, 2010. Research Update. Head. α 1. F 1. α in. α out. P in. P out. P 2. P 1. F in. F out. Internal Organs. α 2. P 2. P 1. F 2. Muscle.

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Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen

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  1. Prepared for the Laboratory for Product and Process Design Created by Eric Lueshen Advisor: Andreas A. Linninger Presented on January 28, 2010 Research Update

  2. Head α1 F1 αin αout Pin Pout P2 P1 Fin Fout Internal Organs α2 P2 P1 F2 Muscle α3 F3 Pharmacokinetics/dynamics Program Figure 2. Basic frame view (top) and pressure distribution (bottom) of simplified drug delivery model. Figure 1. Schematic of simplified drug delivery model.

  3. Nanoparticle Experiments • Fluorescently-labeled PLGA NPs • LNK ChemSolutions • Fluorescent carboxymethyl dextran superparamagnetic NPs • Dr. Barrera • Ultrasound probe = insufficient sonication Figure 3. Comparison in natural light of fluorescently-labeled PLGA NPs (left), water (middle) and fluorescent carboxymethyl dextran MNPs (right).

  4. Other Research • Physiological drug delivery models (rat & human) • ADINA drug transport model • Article draft with Dr. Alex

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