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Advanced Drug Delivery Model Validation and Evaluation

This research project focuses on validating and evaluating a simplified drug delivery model through pharmacokinetics/dynamics programs, dynamic equations, and physiological pressure distribution studies. The study includes extensive validation of solutions, steady-state analysis, dynamic equation generation, and comparisons between continuous and bolus injections with and without mass transfer. Future research involves further dynamics exploration for drug delivery and physiological models for rat and human systems, as well as intrathecal drug delivery considerations.

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Advanced Drug Delivery Model Validation and Evaluation

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  1. Prepared for the Laboratory for Product and Process Design Created by Eric Lueshen Advisor: Andreas A. Linninger Presented on March 11, 2010 Research Update

  2. Figure 2. Basic frame view (left) and pressure distribution (right) of validated simplified drug delivery model. Pharmacokinetics/dynamics Program • Extensive validation of solutions • Steady-state • Dynamic • Finalized dynamic equation generator Figure 1. Validated physiological pressures distributed throughout simplified drug delivery model.

  3. Dynamic Equations: LVP vs. Matlab

  4. Continuous Drug Injection (BLOOD)

  5. Continuous Drug Injection (TISSUE)

  6. Continuous Injection Comparison vs.

  7. Bolus Injection without Mass Transfer

  8. Bolus WITH Mass Transfer (BLOOD)

  9. Bolus WITH Mass Transfer (TISSUE)

  10. Future Research • Finish article draft with Dr. Alex (tomorrow) • Look into more dynamics for drug delivery • Physiological drug delivery models (rat & human) • Intrathecal drug delivery

  11. getConvectionExpression

  12. getCurrentPoint & eqSubString

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