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Basic Structure of Nucleic Acids

Basic Structure of Nucleic Acids. 5’. 1’. 4’. Purine. Pyrimidine. 3’. 2’. Ribose, Deoxyribose. 鹼 基. 磷 酸. Adenine Guanine Thymine Cytosine Uracil. Monophosphate Diphosphate Triphosphate. 五環糖. 核苷. Nucleo s ide (Adenosine). 核苷 酸. Juang RH (2004) BCbasics.

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Basic Structure of Nucleic Acids

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  1. Basic Structure of Nucleic Acids 5’ 1’ 4’ Purine Pyrimidine 3’ 2’ Ribose, Deoxyribose 鹼 基 磷 酸 Adenine Guanine Thymine Cytosine Uracil Monophosphate Diphosphate Triphosphate 五環糖 核苷 Nucleoside (Adenosine) 核苷酸 Juang RH (2004) BCbasics Nucleotide (Adenosine monophosphate, AMP)

  2. Nucleotides Linked by Phosphodiester Bond P R P R P R P R P R P R 1 2 3 2- 2- 5’ O 4 PO4 PO4 - O-P=O 5 O 6 3’ OH 5’ 5’ A kind of phospho-polysaccharides 1 3’ OH 2 Juang RH (2004) BCbasics Phosphodiester bond 3’

  3. The Notation for Nucleic Acids A T C G A T C G 1’ 2’ 3’ 5’ 5’ 3’ P OH 5’pApTpCpGpApTpCpG-OH3’ B 5’pATCGATCG-OH3’ R ATCGATCG P Juang RH (2004) BCbasics

  4. The Two Chains of DNA Are Antiparallel 5’ 3’ 5’pApTpCpGpApTpCpG-OH3’ 5’pCpGpApTpCpGpApT-OH3’ 3’ 5’ Juang RH (2004) BCbasics

  5. Characteristics of Double Helix 3’ 5’ 1 2 3 4 5 6 7 8 9 10 5’ 3’ 36 Å Large groove Small groove 1 Twist = 10.5 bp Juang RH (2004) BCbasics

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