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Digestive System - Pancreas . Pgs. 916-918. Basics . Accessory organ Chyme passes from stomach to small intestine through duodenum Chemical digestion in small intestine depends on the activities of pancreas, liver, and gallbladder . Anatomy of Pancreas .

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Presentation Transcript
basics
Basics
  • Accessory organ
  • Chyme passes from stomach to small intestine through duodenum
  • Chemical digestion in small intestine depends on the activities of pancreas, liver, and gallbladder
anatomy of pancreas
Anatomy of Pancreas
  • Lies posterior to greater curvature of stomach
  • Connected to duodenum by 2 ducts
anatomy of pancreas1
Anatomy of Pancreas

- Pancreas composed of a head, body, and tail

pancreatic ducts
Pancreatic Ducts

- Pancreatic juices are secreted by exocrine cells into small ducts 2 larger ducts

pancreas histology
Pancreas – Histology

- 99% of pancreas = acini

- small clusters of glandular epithelial cells

- exocrine cells – secrete pancreatic juice

  • Other 1% = pancreatic islets (islets of Langerhans)

- endocrine = secrete hormones glucagon,

insulin, etc.

pancreatic juice
Pancreatic Juice
  • 1200-1500 mL produced on a daily basis
  • Consists of water, salts, sodium bicarbonate and many enzymes

- sodium bicarbonate gives pancreas a pH

between 7.1-8.2

- important = buffers acidic gastric juice in

chyme, stops action of pepsin (stomach), and

creates proper pH for digestive enzymes in

small intestine

pancreatic enzymes
Pancreatic Enzymes

Pancreatic amylase – digests starch

Nucleic acid digesting enzymes –

1. ribonuclease

2. deoxyribonuclease

Lipid digesting – pancreatic lipase (most triglycerides)

Protein digesting enzymes =

1. trypsin

2. chymotrypsin

3. carboxypeptidase

4. elastase

protein d igesting enzymes
Protein Digesting Enzymes
  • Most are produced in an inactive form (do not digest cells of the pancreas)

Ex. – trypsin = inactive trypsinogen

- acinar cells also produce trypsin inhibitor that

will destroy any trypsin accidently formed in

pancreas

- trypsinogen into small intestine =

enterokinase – converts trypsinogen into

trypsin activates all other enzymes