Malaria. By: Rebekah Rollston. Quick Facts. Malaria is spread by the bite of the Anopheles mosquito. 350 to 500 million cases of malaria occur annually. More than one million people die annually from malaria.
Targets reticulocytes, which are immature erythrocytes. Reticulocytes comprise 1% of the erythrocyte concentration in the human body.
The pathway that the Plasmodium falciparum merozoites use to invade the erythrocytes depends upon their sensitivity or resistance to neuraminidase, trypsin, and chymotrypsin.
Neuraminidase removes sialic acids.
Trypsin eliminates glycoproteins from the outer surface of erythrocytes, including glycophorin A and glycophorin C.
Chymotrypsin removes glycophorin B and Band 3.Invasion Pathways