1 / 16

Some historical perspectives on Parkinson’s disease

Some historical perspectives on Parkinson’s disease. Resident Conference 6 May 2009 John Peacock MD, PhD. Milestones - 1. James Parkinson: Essay on the Shaking Palsy in 1817 Arvid Carlsson: Discovery of dopamine (DA) in the brain (1950s) –> Nobel Laureate in 2000

kalli
Download Presentation

Some historical perspectives on Parkinson’s disease

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Some historical perspectives on Parkinson’s disease Resident Conference 6 May 2009 John Peacock MD, PhD

  2. Milestones - 1 • James Parkinson: Essay on the Shaking Palsy in 1817 • Arvid Carlsson: Discovery of dopamine (DA) in the brain (1950s) –> Nobel Laureate in 2000 • Ensuing development of dopaminergic medication for Parkinson’s disease (PD)

  3. Founded British Geology Society. No portraits exist.

  4. Parkinson’s Definition of PD • Involuntary tremulous motion, with lessened muscular power, in parts not in action and even when supported with a propensity to bend the trunk forwards and to pass from a walking to a running pace: the senses and intellects being uninjured.

  5. St. Leonard's Church in ShoreDitch, London Baptized Married Buried Here

  6. Arvid Carlsson, PhD • Discovered dopamine in the brain • Set the stage for understanding the biochemical basis of PD • Shared the 2000 Nobel Prize in Medicine • REFERENCES. 1. Carlsson, A. Nobel Lecture, Dec 8, 2000. 2. Carlsson A., Autobiography. Both at Nobelprize.org.

  7. Arvid Carlsson

  8. Receipt of Nobel Prize 2000

  9. Milestones - 2 • MPTP & animal models of PD • Elucidation of electrophysiology of the basal ganglia • Development of rational deep brain neurosurgery in PD

  10. Milestones - 3 • Expansion of clinical knowledge of Parkinson’s disease • Non-motor symptoms • Changes in executive, memory, cognitive, & emotional function • Elucidation of Parkinson plus syndromes

  11. Milestones - 4 • Expansion of knowledge about Lewy bodies & distribution in PD • Discovery of alpha synuclein in Lewy bodies • Advances in genetics of PD (altered alpha synuclein gene)

More Related