some historical perspectives on parkinson s disease l.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Some historical perspectives on Parkinson’s disease PowerPoint Presentation
Download Presentation
Some historical perspectives on Parkinson’s disease

Loading in 2 Seconds...

play fullscreen
1 / 16

Some historical perspectives on Parkinson’s disease - PowerPoint PPT Presentation


  • 139 Views
  • Uploaded on

Some historical perspectives on Parkinson’s disease. Resident Conference 6 May 2009 John Peacock MD, PhD. Milestones - 1. James Parkinson: Essay on the Shaking Palsy in 1817 Arvid Carlsson: Discovery of dopamine (DA) in the brain (1950s) –> Nobel Laureate in 2000

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Some historical perspectives on Parkinson’s disease' - kalli


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
some historical perspectives on parkinson s disease

Some historical perspectives on Parkinson’s disease

Resident Conference

6 May 2009

John Peacock MD, PhD

milestones 1
Milestones - 1
  • James Parkinson: Essay on the Shaking Palsy in 1817
  • Arvid Carlsson: Discovery of dopamine (DA) in the brain (1950s) –> Nobel Laureate in 2000
  • Ensuing development of dopaminergic medication for Parkinson’s disease (PD)
parkinson s definition of pd
Parkinson’s Definition of PD
  • Involuntary tremulous motion, with lessened muscular power, in parts not in action and even when supported with a propensity to bend the trunk forwards and to pass from a walking to a running pace: the senses and intellects being uninjured.
arvid carlsson phd
Arvid Carlsson, PhD
  • Discovered dopamine in the brain
  • Set the stage for understanding the biochemical basis of PD
  • Shared the 2000 Nobel Prize in Medicine
  • REFERENCES. 1. Carlsson, A. Nobel Lecture, Dec 8, 2000. 2. Carlsson A., Autobiography. Both at Nobelprize.org.
slide9

Receipt of

Nobel

Prize

2000

milestones 2
Milestones - 2
  • MPTP & animal models of PD
  • Elucidation of electrophysiology of the basal ganglia
  • Development of rational deep brain neurosurgery in PD
milestones 3
Milestones - 3
  • Expansion of clinical knowledge of Parkinson’s disease
    • Non-motor symptoms
    • Changes in executive, memory, cognitive, & emotional function
  • Elucidation of Parkinson plus syndromes
milestones 4
Milestones - 4
  • Expansion of knowledge about Lewy bodies & distribution in PD
  • Discovery of alpha synuclein in Lewy bodies
  • Advances in genetics of PD (altered alpha synuclein gene)