Key Questions What is the genetic code and how is it read? What role does the ribosome play in assembling proteins? What is the “central dogma” of molecular biology?
Ribosome rRNA Protein Assembly
mRNA Codon– 3 mRNA (genetic code) DNA mRNA to the ribosome
The Steps of Translation • mRNA leaves the nucleus ribosome • AUG-start codon-enters the ribosome • tRNA brings amino acid to the ribosome • Codon and anticodon attach together • Amino acids on the tRNA bind together—peptide bond • tRNA leaves, mRNA shifts down, another tRNA attaches, process repeats until it gets to a stop codon. Forms polypeptide chain (protein) Translation
Central Dogma DNA RNA Protein
Making Proteins DNA T A C A A C G T A C G A A C T mRNA A U G | U U G | C A U | G C U | U G A #1 | #2 | #3 | #4 | #5 Amino Acids AUG– Methionine UUG- Leucine CAU- Histidine GCU- Alanine UGA- Stop