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Pas de coiffe. Intervient dans la synthèse du brin Ө. Intervient dans la régulation de la traduction, la virulence et l’encapsidation. Vpg (24 aam) liaison phosphodiester TRY-pUp, viral protein genome linked. Structure du génome. 740 = AUG. 15 à 90 A = poly A. 7361. 7433. 5’. 3’.

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structure du g nome

Pas de coiffe

Intervient dans la synthèse du brin Ө

Intervient dans la régulation de la traduction, la virulence et l’encapsidation

Vpg (24 aam) liaison phosphodiester TRY-pUp, viral protein genome linked

Structure du génome

740 = AUG

15 à 90 A = poly A

7361

7433

5’

3’

Protéines Protéines

structurales non structurales

organisation du g nome du poliovirus type arnm monocistronique

3’

5’

Traduction

COOH

Polyprotéine (NCVP)

H2N

Clivages protéolytiques

P1

P2

P3

La protéase est active dès sa synthèse dans la NCVP

VP3

VP1

VPg

VP0

VP2

{

VP4

Réplicase

Protéines de capside du virion

Protéase

Organisation du génome du Poliovirus(type ARNm, monocistronique)