Behandling av immunsykdommer. SLE Sjøgrens syndrom Revmatoid artritt Andre autoimmune sykdommer Transplantasjonsreaksjoner. Behandling av immunsykdommer. Glucocortikoider Cytostatika Kalsinevrinhemmere mTOR hemmere Immunoglobuliner Cytokinantagonister. KROPPENS FORSVARSMEKANISMER.
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MHC I presents cytosolic antigens (on all cells)
MHC II presents endocytosed antigens (antigenpresenting cells)
loaded into a antigen-binding groove on the surface
of the MHC molecule
and kill these cells by release of perforins that form channels
in the target cell membrane
the same MHC class (MHC restriction)
proteins that acts like co-
receptors for MHC I and
MHC II, respectively
Intracellularly, CD4 and CD8
are coupled to tyrosine kinases
that participates in the activation
of the T-cell
and TCR are coupled to intra-
cellular signalling pathways
they secrete interleukins (IL2) that induce their proliferation
The clinical course of 24 patients was followed for 4 weeks after treatment with either a placebo or a monoclonal antibody against TNF-α at a dose of 10 mg kg-1.