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The Association Cortex

The Association Cortex. The Neocortex. The Association Cortices ( Brodmann’s Areas). s pace ,time, motion, planning, decision making, emotional reactivity, memory, recall, etc. . HOW DO WE KNOW THIS?????. Association Cortices Across Species. Basic Properties of the Association Cortex.

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The Association Cortex

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  1. The Association Cortex

  2. The Neocortex

  3. The Association Cortices (Brodmann’s Areas) space ,time, motion, planning, decision making, emotional reactivity, memory, recall, etc. HOW DO WE KNOW THIS?????

  4. Association Cortices Across Species

  5. Basic Properties of the Association Cortex • At least 1 primary source of INPUT and OUTPUT from other cortical or sub-cortical brain areas

  6. Thalamus: Gateway of Neural Information • If you recall…. • vision (hearing) made possible through the travel of neuronal information from the retina (cochlea) to the occipital (temporal) cortex via lateral (medial) geniculate leaflet • Pulvinar Nucleus: Parietal Assocation Cortex • Lateral Posterior: Temporal Association Cortex • Medial Dorsal: Frontal Association Cortex

  7. Basic Properties of the Association Cortex • Connections to and from the association cortex on vertical (columnar) and horizontal (lateral) axes

  8. Spatial Representation of Vertical Inputs to Association Cortex

  9. Basic Properties of Association Cortex • Cells with similar functions aligned radially (for the most part) • Any functionally similar cell groups that are aligned horizontally are done so through interneurons

  10. Basic Properties of Association Cortex • Contralateral information travels via the corpus callosum or anterior commissure Disruption: Dyslexia

  11. Damage to Association Cortices • Frontal • Parietal • Temporal • Lesions and Ischemic Damage to these cortices result in neglect or agnosias • Difference: Neglect= “Don’t See It” vs. Agnosia= “See it, but Don’t Know It”

  12. Frontal Damage • Historical case study of Phineas Gage (1800s) and his new polarizing personality

  13. Deficits of Attention, Decision Making, and Gratification • Anterior cingulate cortex • Neuropathology of ADD, for example • Patients perform poorly on Stroop Test

  14. Deficits of Attention, Decision Making, and Gratification • Orbitofrontal Cortex • Neuropathology of OCD and antisocial personality disorder, for example

  15. Deficits in Planning • Dorsolateral Prefrontal • Delayed Response Task is a measure of planning deficiency

  16. Delayed Response Task in Monkeys

  17. Contralateral Neglect Syndrome (Visuospatial Deficit of “Not Seeing”) Parietal Damage

  18. Primarily due to damage of right parietal association cortex

  19. Agnosias (“Seeing, but Not Knowing”) • Great leisurely, science reading on these syndromes by Oliver Sacks -The Man Who Mistook His Wife for a Hat - The Island of the Colorblind • Prosopagnosia • Appreceptive • Akinestopsia • Achromatopisa (*hereditary) Temporal Damage

  20. The inability to differentiate and remember faces due to damage of the inferior temporal lobe Prosopagnosia

  21. An inability to differentiate and remember objects due to damage of the posterior right hemisphere AppreceptiveAgnosia

  22. An inability to differentiate motion due to damage of the medial temporal cortex (“A Life In Still Frames”) Akinestopsia

  23. An inability to differentiate between colors (“A Life in Black and White”) due to a hereditary deficit resulting in improper brain development Achromatopsia

  24. A brain pacemaker • Novel treatment strategy for Parkinson’s and associative disorders like OCD, ADD, and depression Deep Brain Stimulation

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