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SIRIUS Trial: Diameter Restenosis. P<0.001. P=0.001. % Proximal Segment. % In Segment. % Distal Segment. % In stent. P=NS. P=0.14. Coated. Bare. Coated. Bare. Coated. Bare. Coated. Bare. Peristent Restenosis (PSR): 5 mm proximal and distal to the stent

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sirius trial diameter restenosis
SIRIUS Trial: Diameter Restenosis

P<0.001

P=0.001

% Proximal Segment

% In Segment

% Distal Segment

% In stent

P=NS

P=0.14

Coated

Bare

Coated

Bare

Coated

Bare

Coated

Bare

Peristent Restenosis (PSR): 5 mm proximal and distal to the stent

In stent Restenosis (ISR): within the margins of the stent

In Segment: Sum of PSR and ISR

Euro PCR 2002

sirius trial late loss mm
SIRIUS Trial: Late Loss (mm)

P=0.001

P=0.009

P=0.14

P<0.001

In Segment

Distal Segment

Proximal Segment

In stent

Coated

Bare

Coated

Bare

Coated

Bare

Coated

Bare

Peristent Restenosis (PSR): 5 mm proximal and distal to the stent

In stent Restenosis (ISR): within the margins of the stent

In Segment: Sum of PSR and ISR

Euro PCR 2002

sirius trial minimum lumen diameter at follow up mm
SIRIUS Trial: Minimum Lumen Diameter at Follow-Up (mm)

P<0.001

P<0.001

P<0.001

In stent MLD (mm)

In stent MLD (mm)

In stent MLD (mm)

Coated

Bare

Coated

Bare

Coated

Bare

Small Vessels:

Median 2.30

Medium Vessels:

Median 2.79

Large Vessels:

Median 3.00

Euro PCR 2002

sirius trial in stent restenosis at follow up
SIRIUS Trial: In Stent Restenosis at Follow-Up (%)

P<0.001

P<0.001

P=0.002

In stent Restenosis (%)

In stent Restenosis (%)

In stent Restenosis (%)

Coated

Bare

Coated

Bare

Coated

Bare

Small Vessels:

Median 2.30

Medium Vessels:

Median 2.79

Large Vessels:

Median 3.00

Euro PCR 2002

sirius trial in segment restenosis at follow up
SIRIUS Trial: In Segment Restenosis at Follow-Up (%)

P=0.002

P<0.027

P<0.001

In segment Restenosis (%)

In segment Restenosis (%)

In segment Restenosis (%)

Coated

Bare

Coated

Bare

Coated

Bare

Small Vessels:

Median 2.30

Medium Vessels:

Median 2.79

Large Vessels:

Median 3.00

Euro PCR 2002

sirius trial lesion length and ivus findings
SIRIUS Trial: Lesion Length and IVUS Findings

Plaque Volume

NIH IVUS Volume

Restenotic Lesion Length (mm)

Coated

Bare

Coated

Bare

Coated

Bare

Euro PCR 2002

sirius loss index late loss acute gain
SIRIUS: Loss Index (Late Loss / Acute Gain)

In Segment

In Stent

Loss Index

Euro PCR 2002

sirius tlr and tvf
SIRIUS: TLR and TVF

Target Lesion Revasc (TLR)

Target Vessel Failure (TVF)

P<0.001

P<0.001

Incidence (%)

Euro PCR 2002

slide9

SIRIUS: Clinical Events

Incidence (%)

Coated

Bare

Coated

Bare

Coated

Bare

Coated

Bare

Coated

Bare

Coated

Bare

Stent Thrombosis < 24 hrs

Non Q wave MI

Stent Thrombosis Day 1 - 30

Q wave MI

Death

MACE

Euro PCR 2002