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Influence of Remote Ischemic Preconditioning on MMP Activities in Cardiac Tissue Before and After CPB

The study compares MMP activities in cardiac biopsy samples before and after cardiopulmonary bypass (CPB) in patients with low and high cTnT concentrations, analyzing the effects of remote ischemic preconditioning (RIPC) on MMP-2 and MMP-9. Results show an increase in MMP activities in RIPC patients with high cTnT levels. SEM bars used for analysis.

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Influence of Remote Ischemic Preconditioning on MMP Activities in Cardiac Tissue Before and After CPB

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  1. Serum concentration of cTnT Activity of MMP-2/9 Before CPB AfterCPB Supplemental Figure 1 MMP activities in cardiac biopsy samples. The enzymatic activities of pro-MMP-2, MMP-2, pro-MMP-9 and MMP-9 were evaluated in tissue samples from 12 control patients with low cTnT levels (cTnT ≤0.32ng/ml; mean cTnT concentration 0.18±0.02 ng/ml) and 12 RIPC patients with high cTnT concentrations (“non-responder”; cTnT ≥0.32ng/ml; mean cTnT concentration 1.04±0.14 ng/ml . Compared to the control group the activities of both MMPs were by trend increased in the RIPC group with high cTnT levels. Bars denote SEM. CPB, cardiopulmonary bypass; RIPC, remote ischemic preconditioning.

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