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B. Fold Change. Fold Change. CREBH-N. CHOP. ATF4. sXBP1. ATF6 α -N. Fold Change. Fold Change. α - tubulin. α - tubulin. α - tubulin. Supplemental Figure:2. α - tubulin. α - tubulin. A. *. *. *. -. -. -. +. +. +. -. -. +. +. Empty vector. Empty vector. +. -. D. -.

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Supplemental figure 2

B

Fold Change

Fold Change

CREBH-N

CHOP

ATF4

sXBP1

ATF6α-N

Fold Change

Fold Change

α-tubulin

α-tubulin

α-tubulin

Supplemental Figure:2

α-tubulin

α-tubulin

A

*

*

*

-

-

-

+

+

+

-

-

+

+

Empty vector

Empty vector

+

-

D

-

CHOP

**

C

5XATF6αRE

(UPRE)-Luc

*

-

-

-

-

-

CREBH

sXBP1

ATF6α

5XATF6αRE

(UPRE)-Luc

CHOP

ATF4

G6Pase-Luc

GRP78-Luc

CRP-Luc

Fold Change

-

Empty vector

+

+

-

ATF6α

E

ATF4

C/EBP

Empty vector

-

+

+

-

sXBP1

*

Empty vector

-

+

-

CREBH

+