Synthetic Biology - Progess in Merging Nanoparticles and Proteins. Kie Moon Sung David Mosley Joseph Jacobson Center for Bits and Atoms, MIT Beau Peele Shuguang Zhang Biomedical Engineering Dept, MIT. Nanoparticle Building Blocks. COOH. COOH. NH 2. NH 2. COOH. COOH. NH 2. NH 2.
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Kie Moon Sung
Center for Bits and Atoms, MIT
Biomedical Engineering Dept, MIT
Nanoparticle Building Blocks Proteins
Natural amino acids
aReagents and conditions: (a) H2NNH2·H2O/DMF (2% v/v), DIPEA/DMF (10% v/v). (b) HS(CH2)10CO2H (excess), THF. (c) DIC (excess), DMF/THF (10% v/v) rt, 24h. (d) MeNH2, DIC (excess), DMF/THF, rt, 12h. (e) 60% TFA, 2.5% TIS, 2.5% H2O, 35% DMF, 24h.
At least 60% of Nanocrystals are monofunctionalized.
J.Am.Chem. Soc., 126 (2004), p. 5064
Fmoc SPPS Protocols
Ultimate Goals Proteins
All aided by the programmable assembly nature of this building block based technology. This concept will allow us to access completely new motifs, and readily explore the phase space.