Synthetic Biology. 6. Synthetic Biology. What is Synthetic Biology?. Discover Magazine: Scientists of the Year. Undergraduates in Synthetic Bio. international Genetically Engineered Machines. http://parts.mit.edu/registry/index.php/Main_Page. 37 Teams in 2006; 57 in 2007.
Undergraduates in Synthetic Bio. international Genetically Engineered Machines http://parts.mit.edu/registry/index.php/Main_Page
37 Teams in 2006; 57 in 2007 http://parts.mit.edu/r/parts/igem/team_list.cgi
Registry of Parts - iGEM Resource http://parts.mit.edu/registry/index.php/Part_Types
Lego Assembly for DNA Parts http://parts.mit.edu/registry/index.php/Assembly:Standard_assembly
What can you make in SB? Self-organized Pattern Formation Arsenic Detector
Davidson and MWSU Join Forces 2006 iGEM Teams http://parts2.mit.edu/wiki/index.php/Davidson_2006 http://parts2.mit.edu/wiki/index.php/Missouri_Western_State_University_2006
Burnt Pancake Problem: 2006 Sorting stacks of burnt pancakes DNA Pancakes: order and orientation
Davidson & Missouri Western: 2006 http://www.bio.davidson.edu/people/kahaynes/FAMU_talk/Living_computer.swf
Modeling Pancake Flipping -1 2 1 2 1 -2 -1 -2 -2 -1 -2 1 2 1 2 -1 R2: 2 Burnt Pancakes 8 vertices, each with degree 3 Each path taken with probability 1/27
MWSU wins Best Presentation! Five Prizes in 10 Categories!
students Todd wearsa coat & tie! Jeff Poet, Math Prof. GovernorMatt Blunt MO Governor Meets MWSU iGEMmers
Split GFP Works! http://www.bio.davidson.edu/Courses/Immunology/Students/spring2006/Acker/GFP_halfframe.html
SB Blends Math and Biology HHMI Proposals Due Fall, 2007
Is SB hard or expensive? • Hire rising sophomores • Less than $5,000 in lab expenses • NSF Undergraduate Biology and Math Program • Protocols student-proof and online • Creativity and fun encouraged • Existing lab equipment and methods • Math modeling improves design • Fun iGEM competition stimulates students
Hin LVA Tet AraC PC RBS RBS pLac hixC pBad hixC hixC RE T T T T How can SB fit into a curriculum? • Seminar course to prepare • Research or Independent Study to build • Summer research programs • Existing Courses: Molecular Biology, Genetics, Cell Biology, Development, Microbiology, Biochemistry, Engineering, Modeling, Lab Methods...
How can we learn more? • Attend iGEM 2007 in Boston • Read synthetic biology paperswww.bio.davidson.edu/Courses/Synthetic/read.html • Familiarize yourself with iGEM wiki • Form an iGEM team on your campus • Put Synthetic Biology in your HHMI proposal
Is GCAT participating in iGEM? • Encouraging PUIs to join the fun • Including iGEM in HHMI request • Sharing protocols • Making List-serve available • Synthetic biology workshops possible • Develop curriculum and resources to share http://parts.mit.edu/igem07/index.php/Davidson_Missouri_W