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Synthetic Biology - PowerPoint PPT Presentation


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Information in Biology. Synthetic Biology. Mati Cohen. Outline. What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter” . Outline. What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter” .

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Presentation Transcript
outline
Outline
  • What is synthetic biology?
  • Biological Clocks
  • The “Repressilator”
  • Signal transduction
  • The “Diverter”
outline3
Outline
  • What is synthetic biology?
  • Biological Clocks
  • The “Repressilator”
  • Signal transduction
  • The “Diverter”
outline4
Outline
  • What is synthetic biology?
  • Biological Clocks
  • The “Repressilator”
  • Signal transduction
  • The “Diverter”
what is synthetic biology
What is synthetic biology?
  • The design and construction of new biological parts, devices, and systems
    • The “Repressilator”
  • The re-design of existing, natural biological systems for useful purposes.
    • The “Diverter”
outline8
Outline
  • What is synthetic biology?
  • Biological Clocks
  • The “Repressilator”
  • Signal transduction
  • The “Diverter”
biological clocks
Biological - Clocks
  • Three questions
  • How does it work
  • How does it synchronize
  • How does it translate to activity
outline13
Outline
  • What is synthetic biology?
  • Biological Clocks
  • The “Repressilator”
  • Signal transduction
  • The “Diverter”
repressilator
Repressilator
  • oscillations are favored by
    • Strong promoters
    • Efficient ribosome-binding sites
    • Tight transcriptional repression
    • Comparable protein and mRNA decay rates
outline18
Outline
  • What is synthetic biology?
  • Biological Clocks
  • The “Repressilator”
  • Signal transduction
  • The “Diverter”
the yeast system
The Yeast system
  • Scaffold proteins
  • Mediating recruitment
  • Improve efficiency of signal transfer.
  • Facilitate interactions among different signal pathways
  • Control localization of signal proteins within a cell.
outline21
Outline
  • What is synthetic biology?
  • Biological Clocks
  • The “Repressilator”
  • Signal transduction
  • The “Diverter”
summary
Summary

What is synthetic biology?

  • The design and construction of new biological parts, devices, and systems

The Repressilator

  • The re-design of existing, natural biological systems for useful purposes.

The Diverter

signal transduction27
Signal transduction

movies

signal transduction

  • http://www.youtube.com/watch?v=tMMrTRnFdI4

signal transduction

  • http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/part2/signals.htm#animat2