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Figure S1 (related to Fig.1)

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Figure S1 (related to Fig.1). A. B. Figure S2 (related to Fig.2). A. ASXL1 relative expression. Mock/Mock. ASXL1-MT/Mock. Mock/SETBP1-WT. Mock/SETBP1-D868N. ASXL1-MT/SETBP1-WT. ASXL1-MT/SETBP1-D868N. B. SETBP1 relative expression. Mock/Mock. ASXL1-MT/Mock. Mock/SETBP1-WT.

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Presentation Transcript
slide2

FigureS2 (related to Fig.2)

A

ASXL1 relative expression

Mock/Mock

ASXL1-MT/Mock

Mock/SETBP1-WT

Mock/SETBP1-D868N

ASXL1-MT/SETBP1-WT

ASXL1-MT/SETBP1-D868N

B

SETBP1 relative expression

Mock/Mock

ASXL1-MT/Mock

Mock/SETBP1-WT

Mock/SETBP1-D868N

ASXL1-MT/SETBP1-WT

ASXL1-MT/SETBP1-D868N

slide3

C

Relative viability

D

*

*

*

**

*

*

*

*

slide4

E

①Mock/Mock

②ASXL1-MT/Mock

③Mock/SETBP1-WT

④Mock/SETBP1-D868N

⑤ASXL1-MT/SETBP1-WT

⑥ASXL1-MT/SETBP1-D868N

F

Mature cells (%)

*

*

**

**

***

Immature cells (%)

***

**

*

*

*

*

**

**

CD11b MFI

①Mock/Mock

②ASXL1-MT/Mock

③Mock/SETBP1-WT

④Mock/SETBP1-D868N

⑤ASXL1-MT/SETBP1-WT

⑥ASXL1-MT/SETBP1-D868N

slide5

FigureS3 (related to Fig.4)

A

ASXL1 relative expression

ASXL1-MT/SETBP1-D868N

Mock

B

SETBP1 relative expression

ASXL1-MT/SETBP1-D868N

Mock

slide6

C

***

***

Relative growth rate

***

*

D

slide7

E

c-kit

Gr1

ScaI

CD11b

CD34

B220

NGFR

=ASXL1-MT

FcεRIα

SETBP1-D868N (GFP)

slide8

FigureS4 (related to Fig.5)

A

In vitro

In vivo

-

+

-

+

FTY720

P-PP2A

P=0.0906

PP2A

tublin

B

slide10

FigureS5 (related to Fig.6)

A

NES=1.70

P=0.000

AML

MDS

B

NES=1.78

P=0.000

AML

MDS

C

NES=-1.34

P=0.017

AML

MDS

slide11

D

NES=-1.57

P=0.016

AML

MDS

E

NES=-1.13

P=0.071

AML

MDS

F

NES=1.41

P=0.000

AML

MDS

slide12

G

NES=1.42

P=0.021

MDS

Control