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Survival Analysis of MBZ Treatment on Orthotopic Tumor-Induced Mice

Examining the survival rates of mice with orthotopic tumors treated with MBZ. RNA expression of GLI1, PTCH1, and PTCH2 was assessed. Euthanization details provided.

brennan-stephenson
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Survival Analysis of MBZ Treatment on Orthotopic Tumor-Induced Mice

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  1. Figure S1 A B * * GLI1/GAPDH mRNA Survival (%) Vehicle m=61dMBZ m=80d ** Treatment Time (Days) Supplementary Fig S1. (A) Survival of mice with DAOY-derived orthotopic tumors at 25 mg/kg MBZ (n=4) or mock-treated (n=3). One mouse from the mock treatment group did not develop symptoms of a growing brain tumor, and was euthanized after surviving for more than six months. This mouse was not found to have a brain tumor, and was therefore omitted from this analysis. (B) RNA was harvested from untreated and treated tumors and assessed by qRT-PCR for expression of GLI1, PTCH1, and PTCH2.

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