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  1. Featured Article: Relationship of Dopamine Type 2 Receptor Binding Potential With Fasting Neuroendocrine Hormones and Insulin Sensitivity in Human Obesity Julia P. Dunn, M.D., M.S., Robert M. Kessler, M.D., Irene D. Feurer, Ph.D., Nora D. Volkow, M.D., Bruce W. Patterson, Ph.D., Mohammad S. Ansari, M.S., Rui Li, M.S., Pamela Marks-Shulman, R.D., M.S., Naji N. Abumrad, M.D. Diabetes Care Volume 35: 1105-1111 May, 2012

  2. Study Objectives • Midbrain dopamine (DA) neurons, involved with reward and motivation, are modulated by hormones that regulate food intake (insulin, leptin, and acylghrelin [AG]) • Hypothesis: These hormones are associated with deficits in DA signaling in obesity Dunn J et al. Diabetes Care 2012;35:1105-1111

  3. Study Design • Assessed relationships between fasting levels of insulin and leptin, and AG, BMI, and insulin sensitivity index (SI) with the availability of central DA type 2 receptor (D2R) • Measured D2R availability using PET and [18F]fallypride in 8 lean and 14 obese females • Fasting hormones collected prior to scanning • SI determined by modified OGTT Dunn J et al. Diabetes Care 2012;35:1105-1111

  4. Dunn J et al. Diabetes Care 2012;35:1105-1111

  5. Dunn J et al. Diabetes Care 2012;35:1105-1111

  6. Dunn J et al. Diabetes Care 2012;35:1105-1111

  7. Dunn J et al. Diabetes Care 2012;35:1105-1111

  8. Dunn J et al. Diabetes Care 2012;35:1105-1111

  9. Conclusions • Findings provide evidence for an association between the neuroendocrine hormones and DA brain signaling in obese females Dunn J et al. Diabetes Care 2012;35:1105-1111