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Effect of Dasatinib Treatment on Cell Proliferation and Signaling Pathways

This study investigates the impact of dasatinib on cell proliferation and key signaling molecules in cancer cells. Results show dasatinib inhibits cell growth and alters Src, FAK, P130, and Actin pathways.

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Effect of Dasatinib Treatment on Cell Proliferation and Signaling Pathways

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  1. Supplemental Figure 1. Codon L576P CTT →　CCT Wild type Mutation

  2. Supplemental Figure 2. DM440 DM366 nM 0 10 100 1000 0 10 100 1000 Src p-Src FAK p-FAK P130 p-P130 DM6 DM738 Actin WM3211 nM 0 10 100 1000 0 10 100 1000 0 10 100 1000 Src p-Src FAK p-FAK P130 p-P130 Actin

  3. Supplemental Figure 3. % inhibition of cell proliferation with 1000nM dasatinib alone DM440 Src-predicted dysregulation

  4. Supplemental Figure 4. 1 2 3 4 5 6 7 8 Model number Harvest Model1 (Control) Src 0 4hr 8hr 16hr 24hr Dasatinib Harvest p-Src Model 2 FAK A Dasatinib Harvest p-FAK Model 3 P130 Dasatinib p-P130 Harvest Model 4 Actin Dasatinib Harvest Model 5 Dasatinib Dasatinib Harvest Model 6 Dasatinib Dasatinib Harvest B Model 7 Dasatinib Dasatinib Harvest Dasatinib Model 8

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