Yeast Osmoregulation. Content. Introduction Sensing osmotic changing HOG signaling pathways Transcriptional Responses Response To Hyperosmotic Shock Quantitative analyses. Introduction. The osmoregulatory system in the yeast Saccharomyces cerevisiae is particularly well understood.
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Sln1p is a protein of 1,220 amino acids.
Sln1p is the only sensor histidine kinase in the S. cerevisiae proteome.
Sho1p is a protein of 367 amino acids consisting of four predicted transmembrane domains within the N-terminal part, a linker domain, and an SH3 domain for protein-protein interaction.
Recent studies have shown that mucin-like transmembrane proteins Hkr1 and Msb2 are the potential osmosensors and the most upstream elements know so far in the SHO1 branch.
Fig 9 Schematic model of the sequential docking interactions in the SHO1 pathway.
Fig 16 The yeast HOG pathway signaling system and overview of response mechanisms