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Integrating  Cells  into Tissues. Sho Momota. CAM(Cell-adhesion molecules) ECM(Extra cellular matrix). ECM . Proteoglycans Collagen fibers Multiadhesive matrix proteins. CAM. Cadherins Ig (immunoglobulin) super family Selectins Mucins integrins. Ca. N-teminus.

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slide2
CAM(Cell-adhesion molecules)
  • ECM(Extra cellular matrix)
slide3
ECM
  • Proteoglycans
  • Collagen fibers
  • Multiadhesive matrix proteins
slide4
CAM
  • Cadherins
  • Ig (immunoglobulin) super family
  • Selectins
  • Mucins
  • integrins
slide5

Ca

N-teminus

Extra cellular region

  • Cadherins

cell

membrane

50-60% of the sequence is identical among different cadherins.

C-teminus

Cytoplasm

types of cadherin
Types of cadherin
  • More than 40 different cadherins are known
  • E-cadherin : Preimplantation embryos,

non-neural epethelial tissue

  • P-cadherin : Trophblast
  • N-cadherin : nervous system, lens, cardiac and

skeletal muscle

character of cadherin
Character of cadherin
  • Homophilic (like bind like)

E-cadherins bind to E-cadherins

P-cadherins bind to P-cadherins

E-cadherins usually not bind to P-cadherins

n cams
N-CAMs
  • Group of Ca-independent cell-adhesion proteins
  • Ig super family of CAMs
  • Primarily Homophilic interaction
  • Encoded by a single gene.
selectin
Selectin

Blood

Sialyl

Lewis-x

antigen

Endothelial cell

  • Extravasation of leukocytes

require the successive formation and breakage of cell-cell contacts between leukocytes in the blood and endothelial cells lining the vessels

Sugar binding lectin domain

P-selectin

integrin
Integrin
  • Heterodimers of  and  subunits
  • Exhibit relatively low affinities for the ligands
slide11

IIb3 integrin

platelet

Accelerates a formation of clot

Collagen or thrombin

Conformational change of IIb3 integrin

Fibrinogen

platelet

Activated platelet

factors
Deadhesion factors
  • Promote cell migration and can remodel the cell surface

Disintegrins

ECM

RGD sequence

de adhesion factors
De-adhesion factors

CELL

CAM

ECM

Disintegrins