Ｉｎｔｅｇｒａｔｉｎｇ Ｃｅｌｌｓ into Tissues. Sho Momota. CAM(Cell-adhesion molecules) ECM(Extra cellular matrix). ECM . Proteoglycans Collagen fibers Multiadhesive matrix proteins. CAM. Cadherins Ig (immunoglobulin) super family Selectins Mucins integrins. Ca. N-teminus.
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Extra cellular region
50-60% of the sequence is identical among different cadherins.
non-neural epethelial tissue
E-cadherins bind to E-cadherins
P-cadherins bind to P-cadherins
E-cadherins usually not bind to P-cadherins
require the successive formation and breakage of cell-cell contacts between leukocytes in the blood and endothelial cells lining the vessels
Sugar binding lectin domain
Accelerates a formation of clot
Collagen or thrombin
Conformational change of IIb3 integrin