1 / 14

Ｉｎｔｅｇｒａｔｉｎｇ 　Ｃｅｌｌｓ　 into Tissues

Ｉｎｔｅｇｒａｔｉｎｇ 　Ｃｅｌｌｓ　 into Tissues. Sho Momota. CAM(Cell-adhesion molecules) ECM(Extra cellular matrix). ECM . Proteoglycans Collagen fibers Multiadhesive matrix proteins. CAM. Cadherins Ig (immunoglobulin) super family Selectins Mucins integrins. Ca. N-teminus.

marsden-emerson
Download Presentation

Ｉｎｔｅｇｒａｔｉｎｇ 　Ｃｅｌｌｓ　 into Tissues

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Ｉｎｔｅｇｒａｔｉｎｇ　Ｃｅｌｌｓ　into Tissues Sho Momota

  2. CAM(Cell-adhesion molecules) • ECM(Extra cellular matrix)

  3. ECM • Proteoglycans • Collagen fibers • Multiadhesive matrix proteins

  4. CAM • Cadherins • Ig (immunoglobulin) super family • Selectins • Mucins • integrins

  5. Ca N-teminus Extra cellular region • Cadherins cell membrane 50-60% of the sequence is identical among different cadherins. C-teminus Cytoplasm

  6. Types of cadherin • More than 40 different cadherins are known • E-cadherin : Preimplantation embryos, non-neural epethelial tissue • P-cadherin : Trophblast • N-cadherin : nervous system, lens, cardiac and skeletal muscle

  7. Character of cadherin • Homophilic (like bind like) E-cadherins bind to E-cadherins P-cadherins bind to P-cadherins E-cadherins usually not bind to P-cadherins

  8. N-CAMs • Group of Ca-independent cell-adhesion proteins • Ig super family of CAMs • Primarily Homophilic interaction • Encoded by a single gene.

  9. Selectin Blood Sialyl Lewis-x antigen Endothelial cell • Extravasation of leukocytes require the successive formation and breakage of cell-cell contacts between leukocytes in the blood and endothelial cells lining the vessels Sugar binding lectin domain P-selectin

  10. Integrin • Heterodimers of  and  subunits • Exhibit relatively low affinities for the ligands

  11. IIb3 integrin platelet Accelerates a formation of clot Collagen or thrombin Conformational change of IIb3 integrin Fibrinogen platelet Activated platelet

  12. Ｄｅａｄｈｅｓｉｏｎ factors • Promote cell migration and can remodel the cell surface Disintegrins ECM RGD sequence

  13. De-adhesion factors CELL CAM ECM Disintegrins

  14. Question?

More Related