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Detection pulmonary disorders using impulse oscillometry in patients with extrinsic allergic alveolitis L .D. Kiryukhina, G.P.Orlova, M .Y. Kameneva Research Institute of Pulmonology at S aint -Petersburg State Medical University. Introduction :.

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Detection pulmonary disorders using impulse oscillometry in patients with extrinsic allergic alveolitis

L.D.Kiryukhina, G.P.Orlova, M.Y.Kameneva

Research Institute of Pulmonology at Saint-Petersburg State Medical University


Introduction
Introduction patients with extrinsic allergic alveolitis:

Changes of impulse oscillometry (IO) parameters were well studied in patients with obstructive disorders. Investigations of lung mechanics using IO meet less often in patients with combined restrictive and obstructive disorders. Current tests of lung function demand performance of forced and maximal breathing maneuvers and they are difficultly feasible for patients with severe dyspnoea. IO has been developed as a measure of lung function that requires only passive cooperation and may be used with success in patients with severe pulmonary disorders.


Aim of the study
Aim of the study: patients with extrinsic allergic alveolitis

To evaluate the possibility of the impulse oscillometry to detect the pulmonary disorders in patients with mixed lung function abnormalities.


Materials
Materials patients with extrinsic allergic alveolitis:

We observed

57 healthy volunteers

(30 M/27F, mean age 47 ± 1 years)

and

17 patients with extrinsic allergic alveolitis

(8M/9F, mean age 45±3 years).


Methods
Methods: patients with extrinsic allergic alveolitis

  • Spirometry

  • Bodyplethysmography

  • Investigation of lung elastic properties with oesophagus catheter (MasterLab, E. Jaeger).

  • IMPULSE OSCILLOMETRY (MasterScreen IOS, E. Jaeger)


Parameters io
Parameters patients with extrinsic allergic alveolitis IO:

  • Zrs – total respiratory impedance

  • R5 – respiratory resistance at 5 Hz

  • R20 – respiratory resistance at 20 Hz

  • FD Rrs – frequency dependence of respiratory resistance:

    FD Rrs = R5 – R20

  • X5– respiratory resistance at 5 Hz

  • X5 – deviation X5 from predicted value:

    X5 = |X5 – X5pred.|

  • RF – resonant frequency



Respiratory resistance rrs in healthy n 57 and patients with eaa n 1 7
Respiratory resistance with Rrs in healthy (n=57) and patients with EAA(n=17)

kPa/l/c

Hz


Frequency dependence of respiratory resistance fd rrs in healthy n 57 and patients with eaa n 1 7
Frequency dependence of with respiratory resistance FD Rrs in healthy (n=57) and patients with EAA (n=17)


Respiratory reactance xrs in healthy n 57 and patients with eaa n 1 7
Respiratory reactance with Xrs in healthy (n=57) and patients with EAA(n=17)

kPa/l/s

Hz


Deviation x5 from predicted value x5 in healthy n 57 and patients with eaa n 1 7
Deviation X5 from predicted value with X5 in healthy (n=57) and patients with EAA (n=17)


Correlation coefficients (p<0,0 with 3) between lung mechanic parameters and IO parameters in patients with EAA


Conclusio n
Conclusio with n:

The changes of IO parameters were not specific to detect the changes of elastic properties in patients with mixed lung disorders.

IO may be more useful to detect airway disorders in such patients.



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