Loading in 2 Seconds...
Loading in 2 Seconds...
Principal Investigator: John M. Karemaker Co-Investigators: Janneke Gisolf Johannes J. van Lieshout Wim J. Stok J.Phillip Saul Academic Medical Center at the University of Amsterdam, dept. of Physiology, The Netherlands
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Co-Investigators: Janneke Gisolf
Johannes J. van Lieshout
Wim J. Stok
Academic Medical Center at the University of Amsterdam, dept. of Physiology, The Netherlands
Sponsored by Space Research Organisation Netherlands (SRON)Physiological Parameters that predict Orthostatic Intolerance after Spaceflight
Need for reliable in-flight countermeasures.
Project goal: to define a set of preflight tests that predicts who is more liable to develop postflight OI.Background
- ECG (mainly for heart rate measurement)
- thoracic impedance;
- finger blood pressure (Finapres);
- TransCranial Doppler (TCD) blood flow velocity of the middle cerebral artery;Hypothesis
Thigh-cuffs: inflated or deflated.
Results preflight vs. duration of postflight standtestObjectives
L-180 lab session in Amsterdam (3hrs)
Cardiovascular reflex responses to challenges on tilt table:
- fast tilt up: supine upright;
- paced breathing (from ~ 1 per 15s. to 1 per 3s. supine & upright);
- thigh-cuffs (inflated or deflated).
- sinusoidal tilts (from ~1 in 30s. to 1 in 3s.)
No in-flight experiments
Morning session: light breakfast
Afternoon session: lunch 2 hrs before the startProtocol explanation
Blood pressure cuffs around the thighs to constitute a hindrance for venous blood return. Will be inflated temporarily
Tilt table has foot and shoulder supports, and safety belts. Can be tilted swiftly and smoothly.Protocol explanation
This protocol is designed to categorize the cardiovascular reaction pattern of a person and act as predictor for the outcome of the test. As test outcome we use the normal stand test that is part of the medical check-up immediately after return. Astronauts are asked to stand relaxed, leaning against a wall or some other fixed object for a maximum of 10 minutes. Orthostatic intolerance is defined as the inability to stand for 10 minutes.
The upright time before this test should be minimal, since hormonal re-adaptation to 1 G starts immediately after resumption of upright Earth-bound life.Summary