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Proinflammatory Mediators Induce HGF–CDK4(R24C) Melanoma Cell Dedifferentiation

Study reveals how proinflammatory signals stimulate HGF–CDK4(R24C) mutation-driven melanoma cells to undergo dedifferentiation, hindering recognition by gp100-specific CTLs. Published in Nature, the findings shed light on a critical aspect of melanoma progression.

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Proinflammatory Mediators Induce HGF–CDK4(R24C) Melanoma Cell Dedifferentiation

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  1. Proinflammatory mediators directly promote HGF– CDK4(R24C) melanoma cell dedifferentiation leading to impaired recognition by gp100-specific CTLs. J Landsberg et al.Nature000, 1-5 (2012) doi:10.1038/nature11538

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