design project using bacteria to cure iron deficiency anemia n.
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Design Project: Using Bacteria to Cure Iron Deficiency Anemia
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  1. Design Project: Using Bacteria to Cure Iron Deficiency Anemia Katherine Kenneally

  2. Most common nutritional deficiency in the world • Iron deficiency is when there is too little iron in the body • Iron deficiency anemia- body does not have enough iron to make healthy red blood cells • Has many severe health consequences • Affects 30% of world’s population Iron Deficiency/Anemia

  3. Provide back-up source of iron to prevent development of iron deficiency • Build upon and improve body’s already existing iron regulation mechanism • Engineer bacteria to produce modified form of protein that stores and releases iron Solution Overview

  4. All other treatments used to treat iron deficiency/iron deficiency anemia when diagnosed • Some examples: • Iron therapy: only for severe anemia, iron injected into muscle or through IV • Iron supplements: pills or liquid • Diet adjustments: eating more iron rich foods • Vitamin C: helps body absorb iron better • Treatment continues for 3-12 months Competing Technology

  5. Bacteria will live in small intestine • Engineer bacteria to produce modified ferritin • Ferritin- protein that stores iron and releases it when needed • Bacteria will produce ferritin that has more stored iron than normal Design Proposal

  6. Bacteria will have AND gate • Need to parts for transcription: an iron sensitive promoter and a repressor that transferrin will bind to when there are increased transferrin levels. Design and Function of Bacteria

  7. Prevents iron deficiency from developing • Easier for people in developing countries or those who cannot pay for doctor visits • Enormous positive health impact • Saves money • Immediate help • Increases productivity Advantages and Effects

  8. Very small chance of any problems, bacteria are very safe • Problems that could occur (all very unlikely): • Hard to get to people everywhere • Mutations could damage either ferritin or bacteria • Take precautions to protect health and environment • Only inefficiency: iron not produced/released directly • Initial introduction of bacteria is invasive Potential Problems

  9. Test first on mice • Have control mice and mice given iron deficient diet • Some mice on low iron diet given bacteria • Monitor all mice Testing