Robert D. Welch, MD, MS Department of Emergency Medicine WSU School of Medicine. Biomarkers for Acute Traumatic Brain Injury. Goals. Discuss current and potential new biomarkers that can aid in the diagnosis and management of patients with TBI Diagnostic CT MRI Serum Biomarkers
Compliments of E. Mark Haacke, Ph.D. and Zhifeng Kou, Ph.D.
WSU MR Research Facility
MR Research Center HUH
SWI - Hemorrhage
FA Z-map (DTI) – White Matter Shearing
Elevated Levels of Serum Glial Fibrillary Acidic Protein Breakdown Products in Mild and Moderate Traumatic Brain Injury Are Associated With Intracranial Lesions and Neurosurgical Intervention
Papa, L, et al. Ann Emerg Med. 2012;xx:xxx.
(Papa, et al: Crit Care Med 2010; 38:138 –144)
Later apoptosis (caspase-3 mediated)