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How Proteins Are Made CHAPTER 10

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How Proteins Are Made CHAPTER 10. DNA, genes, chromosomes. How does a chemical control so much?. DNA. Deoxyribo Nucleic Acid. Sugar: deoxy ribose Phosphate: H 2 PO 4. Nitrogen base: Adenine Guanine Thymine Cytosine. Answers

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slide1
How Proteins

Are Made

CHAPTER 10

dna genes chromosomes

DNA, genes, chromosomes

How does a chemical control so much?

slide3
DNA
  • Deoxyribo
  • Nucleic
  • Acid
sugar deoxy ribose phosphate h 2 po 4
Sugar: deoxy ribosePhosphate: H2PO4
  • Nitrogen base:
    • Adenine
    • Guanine
    • Thymine
    • Cytosine
slide6
Answers

1. Proteins are chains of linked amino acids that have been folded into compact shapes. Some proteins play important roles as enzymes. Other proteins are structural components of cells and tissues.

2. Ribosomes are structures built of proteins and RNA that serve as assembly sites for protein synthesis.

3. DNA is an extremely long, linear molecule containing many genes; genes are relatively short segments of DNA that code for protein or RNA.

4. DNA is made of two strands of complementary nucleotides and contains the four bases adenine, thymine, cytosine, and guanine. DNA contains the sugar deoxyribose and serves to store the complete set of an organism’s genetic material.

5. In DNA, adenine (A) pairs with thymine (T), and guanine (G) pairs with cytosine (C).

general vocabulary
General Vocabulary

1. gene

2. chromosome

3. chromosomal mutation

4. codon

5. double helix

6. frameshift mutation

7. messenger RNA mRNA

8. monosomy

9. mutation

10. nitrogen base

11. nondisjunction

12. point mutation

13. replication

14. ribosomal RNA rRNA

15. transcription

16. transfer RNA tRNA

17. translation

18. trisomy

19. anticodon

20. protein

chapter 10 vocabulary
Chapter 10 Vocabulary
  • Section 1
  • ribonucleic acid (RNA) (208)
  • uracil (208)
  • transcription (208)
  • translation (208)
  • gene expression (208)
  • RNA polymerase (209)
  • messenger RNA (211)
  • codon (211)
  • genetic code (211)
  • transfer RNA (212)
  • anticodon (212)
  • ribosomal RNA (212)
  • Section 2
  • operator (216)
  • operon (216)
  • lac operon (216)
  • repressor (216)
  • intron (218)
  • exon (218)
  • point mutation (219)
slide9

The instructions for building a protein are found in a gene and are “rewritten”to a molecule of RNA during transcription. The RNA is then “deciphered” during translation

slide10
The instructions needed to make proteins are coded in the nucleotides that make up a gene. The instructions are transferred to an mRNA molecule during transcription
slide12
From Genes to Proteins

.

The RNA is complementary to the gene, and the RNA nucleotides are put together with the help of RNA polymerase.

slide14
During translation, the mRNA molecule binds to a ribosome, and tRNAs carry amino acids to the ribosome according to the codons on the mRNA.
slide18
The amino acids are joined to form a protein. The genetic code (codons) used by most organisms to translate mRNA is nearly universal.
gene regulation and structure
Gene Regulation and Structure

Prokaryotic and eukaryotic cells are able to control which genes are expressed and which are not, depending on the cell’s needs.

In prokaryotes, gene expression is regulated by operons.

Gene expression is switched off when repressor proteins block RNA polymerase from transcribing a gene.

slide24
In eukaryotes, an enhancer must be activated for a eukaryotic gene to be expressed. Transcription factors initiate transcription by binding to enhancers and to RNA polymerases.

Repressors are proteins that bind to the operon and physically block RNA polymerase from producing mRNA

slide26
Many eukaryotic genes are interrupted by segments of DNA that do not code for proteins; these segments are called introns.

The segments of DNA that are expressed are called exons.

slide27

After transcription, the introns are cut out, and the exons are joined. The exons are then translated.

slide28
Mutations are changes in DNA. Gene alterations are mutations that change a gene. These mutations can involve a change in a single nucleotide or an entire gene.
what does dna do
What does DNA do?
  • It contains all of the instructions to make the proteins living things need for life!
how can all of that information fit into a single cell
How can all of that information fit into a single cell?
  • DNA is a long chemical molecule with only 4 different nucleotides.
  • It is the sequence of these nucleotides that makes each organism different.
a t c c g g g a g
A-T-C-C-G-G-G-A-G
  • This little piece of DNA had three codes:
  • ATC
  • CGG
  • GAC
in triplets or codons
In triplets or codons
  • The order of the bases makes all of the difference!!!
  • Change one letter and it is totally different.
  • Just like EAT is not the same as TEA
  • Same letters, different order= new meaning!!
dna replication
DNA Replication
  • When new cells are made, DNA must make a copy of it self.
  • This process is called DNA replication.
the original molecule serves as a pattern for the new
The original molecule serves as a pattern for the new
  • The new strand is called complementary to the old one.
translation
Translation
  • How to “translate” the code into proteins
dna is in the nucleus
DNA is in the nucleus
  • Messenger RNA comes into the nucleus and makes a copy of the section of DNA needed.
  • DNA unzips the section and RNA nucleotides copy the DNA
  • The mRNA takes the message out to the cytoplasm
  • RNA polymerase is the enzyme that does this!
slide44
Ribosomal RNA Reads the code by matching up with the messenger RNA and connecting the correct transfer RNA to the mRNA
transfer rna has the anticodon
Transfer RNA has the anticodon
  • mRNA has the codon
  • These match up like the strands of DNA.
slide46
tRNA
  • Each tRNA has an amino acid attached to it
slide47
rRNA
  • Ribosomal RNA “reads” the codon and attaches the correct anticodon.
  • The amino acids attached to the tRNA get bonded together to form a protein.
slide48
There are start and stop codes.
  • There are even enzymes that look for mistakes and make corrections.
  • Bu sometimes mistakes happen…
mutations
MUTATIONS
  • A change in DNA
point mutations
Point mutations
  • A single base pair is changed.
  • THE DOG BIT THE CAT
  • THE DOG BIT THE CAR
  • Only one letter is different yet….
frame shift mutation
Frame shift Mutation
  • A single base is added or deleted
  • This causes the entire line to be read differently!!!
  • CCG AAU GGU
  • ADD ONE C AND
  • CCCGAAUGGU READS
  • CCC GAA UGG U
chromosomal mutations
CHROMOSOMAL MUTATIONS
  • Parts of chromosomes break off
  • Join to the wrong chromosome
  • Chromosomes do not separate correctly during meiosis: non disjunction
trisomy monosomy
Trisomy monosomy
  • Three where there should be two
  • Or
  • One where there should be two.
essay
Essay
  • Explain the process of making a protein from start to finish.
  • Make sure your steps are in the correct sequence.
  • Add as many details as possible.
  • Name the processes and the enzymes.
  • The more items listed, the more points.
  • Do not contradict yourself.
exchange papers
Exchange papers
  • Check to see if all of the parts are there and they are in order.
  • Give a point for each of the items included in the paper.
  • Count up the points.
  • Give the paper back to the owner…
  • How did you do?
things that should be in the answer
Things that should be in the answer:

1. Starts in the nucleus with the DNA gene.

2. DNA to RNA is called transcription

3. RNA polymerase is the enzyme that unzips and transcribes DNA to RNA.

4. Complimentary bases A-U, T-A, C-G, G-C ( no Thymine in RNA)

5. mRNA goes out of nucleus to the cytoplasm to find a ribosome.

6. Ribosome matches mRNA to tRNA

7. mRNA has the codon

8. codon is a set of 3 nitrogen bases that codes for an amino acid.

9. tRNA has the anti codon on one end

10. tRNA has the amino acid on the other end

11. ribosome has an A and a P site

12. amino acids bond together with peptide bonds to form proteins

13. The part of the process that occurs on the ribosome is called translation

incomplete dominance
Incomplete dominance
  • A mixture of the two phenotypes
  • Produces a new
  • Phenotype.
  • Red X White = Pink
co dominance
Co dominance
  • Both are expressed
  • Like a dog with several colors fir
multiple alleles
Multiple alleles
  • More then two alleles for a trait.
  • Like eye color or skin color
  • A range of colors result not just two.