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The Plague

The Plague. a little bit o’ history…. aka- The Black Death 14 century Europe Killed 1/3 of population. www.imageenvision.com/md/stock_photography/00. a nursery rhyme?. Ring around the rosies -> symptomatic red patches on the skin

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The Plague

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  1. The Plague

  2. a little bit o’ history… • aka- The Black Death • 14 century Europe • Killed 1/3 of population

  3. www.imageenvision.com/md/stock_photography/00... a nursery rhyme? • Ring around the rosies -> symptomatic red patches on the skin • Pocket full of posies -> people would carry roses in their pockets in attempts to ward off the disease • Ashes, Ashes -> burn the dead bodies • We all fall down -> 1/3 of the population dead

  4. so what caused the Plague? i’m glad you asked! • Yersiniapestis • Gram negative bacteria • Rod shaped • Facultative anaerobe http://www.eiu.org/experiments/dispersion/images/black_plagueC_icon.jpg

  5. and how does one get this? • Transmitted directly by flea bites http://www-cs-faculty.stanford.edu/~eroberts/courses/ww2/projects/chemical-biological-warfare/plague_files/image001.jpg

  6. so how is it so deadly? http://www.utmb.edu/gsbs/microbook/images/fig29_6.jpg

  7. virulence factors aye? • Virulence factors are located on multiple plasmids • Yops • F1

  8. so how do i know if i have it? • Symptoms develop abruptly in 1-6 days • Sudden: • High fever • Patchy bleeding (rash) under the skin [DIC] • Large lymph nodes • DIC • Bloody sputum • shock

  9. is this treatable? • In 14c Europe: NOPE • But today… • Tetracycline within 12-15 hours of fever onset • Vaccine • Rat control

  10. so does the plague still exist?

  11. References • MICROBIOLOGY: A Human Perspective, sixth edition. Nester. 2009. • http://en.wikipedia.org/wiki/Yersinia_pestis • http://www.cdc.gov/ncidod/dvbid/plague/epi.htm

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