Prevention & Sterilization. Size is Relative. Biofilm Formation. Biofilm Formation. the biological mechanisms are poorly understood therefore mitigating strategies have to focus decreasing initial bioburden
When planning a cleanroom operation, particular attention must be paid to dust sources.
Numbers of Particles Produced per Minute
Seated or standing (not moving)
Seated (making slight movements)
Seated (moving arms or trunk)
Moving from sitting to standing
Walking up steps
15,000,000 – 30,000,000Particulate Matter Produced by Human Activities
There is no ideal sterilization process but in general:
The biological activity of endotoxin is associated with the lipopolysaccharide (LPS). Toxicity is associated with the lipid component (Lipid A) and immunogenicity is associated with the polysaccharide components.