Immunity. State of protection against foreign organisms or substances ('antigens') Defence against disease Defence against tumours. Figure 1. Immune responses are directed at our barriers with the environment. Innate Immunity.
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Immune responses are directed at our barriers with the environment
The immune system is compartmentalised to enable lymphocytes to come into contact with pathogens/antigens.
Structure of the B cell receptor
Structure of the TCR and it’s interaction with MHC/peptide complexes
fight extracellular pathogens. (can produce soluble mediators = cytokines….)
Normally self peptides are expressed in class I MHC.
fight intracellular pathogens. (can lyse body cells!!!)
a) recognise pathogen
b) make an immune response
Pre- T cell into the thymus:
Positive selection: TCR binds to MHC= GROW
Negative selection: TCR has high affinity for MHC+self peptide = DIE
mature T cell
Structure and function of the thymus
Stimulate specific adaptive immune response (antibodies; T cells)
Vaccination protocols, effect on disease prevalence and immune response