Immunity. State of protection against foreign organisms or substances ('antigens') Defence against disease Defence against tumours. Figure 1. Immune responses are directed at our barriers with the environment. Innate Immunity.
Immune responses are directed at our barriers with the environment
The immune system is compartmentalised to enable lymphocytes to come into contact with pathogens/antigens.
Structure of the B cell receptor
Structure of the TCR and it’s interaction with MHC/peptide complexes
fight extracellular pathogens. (can produce soluble mediators = cytokines….)
Normally self peptides are expressed in class I MHC.
fight intracellular pathogens. (can lyse body cells!!!)
a) recognise pathogen
b) make an immune response
Pre- T cell into the thymus:
Positive selection: TCR binds to MHC= GROW
Negative selection: TCR has high affinity for MHC+self peptide = DIE
mature T cell
Structure and function of the thymus
Stimulate specific adaptive immune response (antibodies; T cells)
Vaccination protocols, effect on disease prevalence and immune response