1 / 1

Background and Objective

graham-coleman
Download Presentation

Background and Objective

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The association between perfluoroalkyl chemical levels in umbilical cord blood and birth outcomesTing-Wen Wen1, Mei-Huei Chen1, Guang-Wen Lien1, Wu-Shiun Hsieh2, Chia-Yang Chen3, Yi-Ning Su4,5, Pau-Chung Chen11Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University Collage of Public Health; 2Department of Pediatrics, National Taiwan University College of Medicine and Hospital; 3Institute of Environmental Health, National Taiwan University Collage of Public Health; 4Department of Medical Genetics, National Taiwan University Hospital; 5Institute of Clinical Genomics, National Taiwan University College of Medicine, Taipei, Taiwan The perfluoroalkyl chemicals (PFCs) are persistent organic pollutants and commonly used worldwide. In animal and human studies, exposure to PFOS and PFOA is associated with adverse health effects. The purpose of the present study is to analyze the plasma concentrations of PFCs in umblical cord blood in Taiwan, and moreover, to examine the association between perfluorinated chemicals and metabolic syndrome in this study population. The study population consisted of 456 postpartum women collected from four hospitals and clinics in northern Taiwan. We interviewed them by a structured questionnaire after delivery and collected maternal and cord blood at birth. The concentration of PFCs in umbilical cord blood was analyzed by ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS). We examined the association between newborn birth outcomes and log10 transformed PFCs levels by linear regression models. Background and Objective Results and Discussion Table 1. Distribution of birth outcome Material and Methods Table 3. Concentration of perfluoroalkyl chemicals (ng/mL) by characteristics of study subjects (n=455) Figure 1. The flow chart of sample preparation Table 4. Linear regression model of birth outcome and perfluoroalkyl chemicals exposure (ng/mL) (n=455△) Figure 2. UPLC-MS/MS chromatogram of a bovine plasma extract spiked with perfluoroalkyl chemicals (50 ng/mL) . Table 1. Concentrations of perfluoroalkyl chemicals (ng/mL) in umbilical cord blood Conclusions Our data suggest inverse association between PFOS levels in umbilical cord blood plasma and birth outcomes. Because of widespread exposure to variety perfluoroalkyl chemicals, further studies should explore other PFCs. Corresponding author’s e-mail: pchen@ntu.edu.tw; First author’s e-mail: r97841014@ntu.edu.tw OMIH

More Related