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Tissue Engineering of the Heart. By: Dan Tamayo. Problem Being Solved. Regenerate heart tissues that have been damaged by Myocardial Infarction Help those with heart failure End the need for a heart transplant list. History of Tissue Engineering.

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Presentation Transcript
problem being solved
Problem Being Solved
  • Regenerate heart tissues that have been damaged by Myocardial Infarction
  • Help those with heart failure
  • End the need for a heart transplant list
history of tissue engineering
History of Tissue Engineering
  • 1897-thoughts of growing cells were being discussed
  • 1907- the first cells were grown outside of a living body
  • 1940’s- the ability to specifically grow certain cells was discovered
  • 1970’s- first artificial pancreas was made
  • Mid 1990’s- starting to use direct tissue delivery to the affected area
  • 1998- the development of stem cells really broadened the tissue engineering possibilities
history continued
History Continued
  • 2001-President Bush restricts the funding for stem cell research
  • Mid 2000’s- FDA approves most cells grafting into human bodies
  • 2009-Obama lifts the ban on federal funding for stem cell research.
state of the art technology
State of the Art Technology
  • Today, scientists have been able to use the extracellular matrix from pig or rat hearts to make a new one using a technique called decellularization.
  • In 2011, Columbia University’s Biomedical Engineering researchers developed a new way to patch a heart.
slide6

This is the process of decellularization and recellularization.

  • Decellularization is when all the cells are removed except for the extracellular matrix (top)
  • Recellularization is when the new cells are grow in and around the new heart scaffold (bottom)
tissue scaffolds
Tissue Scaffolds

Empty Scaffold

Scaffold with cultured heart cells from a rat

limitations
Limitations
  • Small chance of immunorejection
  • Cost
  • Research
future
Future
  • Optimal scaffold for cardiac tissue will be found
  • Ability to re-grow a heart from your cells to be transplanted into your body
work cited
Work Cited
  • "Mending Broken Hearts with Tissue Engineering." MIT's News Office. Web. 26 Mar. 2012. <http://web.mit.edu/newsoffice/2008/heart-1102.html>.
  • Zimmermann, Wolfram-Hubertus, Michael Didie, Stephan Do¨ Ker, Ivan Melnychenko, Hiroshi Naito, Christina Rogge, MalteTiburcy, and Thomas Eschenhagen. "Heart Muscle Engineering: An Update on Cardiac Muscle Replacement Therap."Cardiovascular Research 17 (2006). Web.
  • Tandon, Nina, Anna Marsano, Robert Maidhof, Leo Wan, Hyoungshin Park, and GordanaVunjak-Novakovic. "Optimization of Electrical Stimulation Parameters for Cardiac Tissue Engineerin." JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2011). Web.
  • Eschenhagen, Thomas, and Wolfram H. Zimmermann. "Circulation Research." 97.1220-1231 (2005). Web.
  • Van Winterswijk, Peter J., and Erik Nout. "An Overview: History of Tissue Engineering."Tissue Engineering and Wound Healing (2007). Web.
  • "Engineers Patch a Heart: Tissue-Engineering Platform Enables Heart Tissue to Repair Itself."ScienceDaily. ScienceDaily, 06 May 2011. Web. 26 Mar. 2012. <http://www.sciencedaily.com/releases/2011/05/110506171905.htm>.
  • Zammaretti, Prisca, and Marisa Jacon. "Cardiac Tissue Engineering: Regeneration of the Wounded Heart." Current Opinion in Biotechnology 15.430-434 (2004).Http://www.sciencedirect.com/. Web.
  • Columbia University. "Engineers patch a heart: Tissue-engineering platform enables heart tissue to repair itself." ScienceDaily, 7 May 2011. Web. 22 Oct. 2012.