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Tissue Engineering

Tissue Engineering. By Tyler Gagan BME 281 Section 2. Overview. Isolation of patients cell Creation of synthetic scaffold Proliferation of cells onto scaffold. History. 1970’s: ( John F. Burke) First skin substitute. Purified shark collagen, long sugar molecule.

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Tissue Engineering

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  1. Tissue Engineering By Tyler Gagan BME 281 Section 2

  2. Overview • Isolation of patients cell • Creation of synthetic scaffold • Proliferation of cells onto scaffold

  3. History • 1970’s: (John F. Burke) First skin substitute. Purified shark collagen, long sugar molecule. • 1970’s-1980’s First successful human derived skin substitute procedure (Howard Green, Harvard Medical)

  4. Modern Application • Repair of damaged cells • Replacing non-existent cells • Artificial organ parts/entire organs

  5. Limitations • Very long cell adhesion time. • Thick tissues need vascularization. • Proper cell environment is tough to mimic.

  6. Future • Increased growth rate and adhesion rate • Growth of entirely biocompatible organs. • Stocked tissue databases.

  7. Sources • "Research Current Research Programs." Pittsburgh Tissue Engineering Initiative. N.p., n.d. Web. 08 Oct. 2012. <http://www.ptei.org/interior.php?pageID=274>. • "Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges." - Annual Review of Chemical and Biomolecular Engineering, 2(1):403. N.p., n.d. Web. 08 Oct. 2012. <http://www.annualreviews.org/doi/full/10.1146/annurev-chembioeng-061010-114257>. • "Tissue Engineering." Tissue Engineering. N.p., n.d. Web. 08 Oct. 2012. <http://www.atp.nist.gov/focus/tissue.htm>. • "Tissue-Engineering." Tissue-Engineering. N.p., n.d. Web. 08 Oct. 2012. <http://tissue-engineering.net/>.

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