Drill Using your notes or not! Create a graphic organizer (2 column chart) on Skin Cancer. Name the 3 types of skin cancer and their characteristics.
What happens to the cells’ DNA? • Overexposure to the UV radiation in sunlight • Damages DNA bases • UV radiation also disables a tumor suppressor gene (p53) or the patched (ptc) gene. • Sunburn accelerates its production of “Fas,” a protein that causes genetically damaged skin cells to commit suicide… thus reducing the risk of mutations that will cause sun-linked skin cancer. (This is what causes the skin to peel.)
Metastasize “To spread from one part of the body to another. When cancer cells metastasize and form secondary tumors, the cells in the metastatic tumor are like those in the original (primary) tumor.” UNCONTROLLED ABNORMAL MITOSIS!
Basal Cell Carcinoma • Least malignant • Most common skin cancer • Stratum basale cells prolifrate invading the dermis and hypodermis • CURABLE! US National Library of Medicine - Basal Cell Carcinoma
Squamous Cell Carcinoma • Keratinocytes of the stratum spinosum • Lesions scaly reddened papule • Found in head, scalp, ears and lower lip • Grows rapidly • Metastasizes if not removed • Chance of survival good if removed in time. US National Library of Medicine - Squamous Cell Carcinoma
Melanoma • Cancer of melanocytes • Most dangerous • Highly metastatic; resistent to chemo • Incidences are increasing the US! US National Library of Medicine - Melanoma
ACS • A Asymmetry • B Border irregularity • C Color • D Diameter
Burns Rule of Nines
1st Degree Burns • least serious burns • outer layer of skin is burned • skin is usually red, with swelling, and pain sometimes is present Treat a first-degree burn as a minor burn unless it involves substantial portions of the hands, feet, face, groin or buttocks, or a major joint, which requires emergency medical attention.
2nd Degree Burns • first layer of skin has been burned through second layer of skin (dermis) • blisters develop • the skin takes on an intensely reddened, splotchy appearance • severe pain and swelling If the second-degree burn is no larger than 3 inches (7.6 centimeters) in diameter, treat it as a minor burn. If the burned area is larger or if the burn is on the hands, feet, face, groin or buttocks, or over a major joint, treat it as a major burn and get medical help immediately.
3rd Degree Burn • most serious burns • involve all layers of the skin and cause permanent tissue damage • fat, muscle and even bone may be affected • Areas may be charred black or appear dry and white. Difficulty inhaling and exhaling, carbon monoxide poisoning, or other toxic effects may occur if smoke inhalation accompanies the burn.