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Introduction. develop from limb buds3 developmental axes: proximo-distal, antero-posterior, and dorso-ventralearly limb bud: progress zone, apical ectodermal ridge, polarizing region. . . . Ant.. Post.. Dist.. Prox.. Vent.. Dors.. Polarizing region. Progress zone. Apical ectodermal ridge. Apical Ectodermal Ridge (AER).

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