Supplementary Figure S1

1. Supplementary Figure S1 SGI CDDP A. B. biweekly biweekly QD5 SGI+CDDP SGI+CDDP QD5 SGI CDDP Day -3 1 4 8 11 15 22 EOS Day -3 1 2 3 4 5 8 EOS Day 1 4 8 11 15 18 22 25 29 EOS Day 1 2 3 4 5 8 EOS

2. Supplementary Figure S2 A. B. C.

3. Supplementary Figure S3

4. Supplementary Figure S4

5. Supplementary Figure S5 OAW28 A2780 OVCAR8 Day 4 Day 7 Day 4 Day 7 Day 4 Day 6 0 0.1 0.3 1 0.10.3 1 [SGI110] µM 0 0.1 0.3 1 0 0.3 1 [SGI110] µM 00.1 0.3 1 0.1 0.3 [SGI110] µM MLH1 MLH1 MLH1 Actin Actin Actin A. B.

6. Supplementary Figure S6

7. Supplementary Figure S7 A. B. QD5 Biweekly

8. Supplementary Figure S8 A. B.

9. Supplementary Figure S9 A. B. Biweekly QD5 C. D. QD5 Biweekly

10. Supplementary Figure S10 * QD5 A. B. * * Biweekly *

11. Supplementary Figure S11 A. B.