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The T-Cell Receptor

The T-Cell Receptor

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The T-Cell Receptor

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  1. The T-Cell Receptor MHC Restriction TCR Structure & Function Genetic Generation of TCR Diversity Thymus T-cell "Education" and Immunological Tolerance Folder title: Receptor November 15, 2006 TCRTitle

  2. Comparison of T-Cell Receptors (TCR)and Antibodies:Differences Antibody Can be membrane bound; Secreted in large amounts. Recognizes Antigen alone: Soluble or particulate No accessory molecules involved Not MHC Restricted TCR Remains Membrane-bound. Present in small amounts. Recognizes binary complex: Antigen and MHC Protein Associated with CD3, CD4, & CD8 AccessoryMolecules Is MHC Restricted TCRvsAb1

  3. Comparison of T-Cell Receptors (TCR)and Antibodies:Similarities TCR and Ab Rearrange V, J, and (Sometimes) D Germ-line Genes, link these, and join them to C-region Genes, during somatic cell differentiation. (V, J, D and C region germ-line genes are different for TCR vs Ab) Have Complementarity Determining Regions (CDR's) that are hypervariable Recognize an enormous variety of antigenic determinants TCRvsAb2

  4. See Figure 8-15, Kuby, 6th Edition p. 207

  5. MHCRestr Self-MHC Restriction of TCR Kuby, 6th Edition, Fig 9-1, p. 224

  6. Figure 10-5. Top. Kuby, 6th Edition, p. 249

  7. Figure 10-5. Bottom. Kuby, 6th Edition, p. 249

  8. See Figure 9-3, Right Side, Kuby, 6th Edition, p. 226

  9. (costimulates) costimu (inhibits)

  10. Generation of Alpha and Beta Subunits of TCR from Germ-line DNAFigure 11-6, Kuby 3rd Edition

  11. See Table 9-3, Kuby, 6th Edition, p. 229

  12. Allo-Reactivity of T-Cells: orWhy Do T-cells Frustrate Transplant Surgeons? Figure 11-1 Kuby, 3rd Edition AlloKill