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Comparative Analysis of RSV Infection in BALB/c and C57BL/6 Mice Models

This study investigates the immune response to Respiratory Syncytial Virus (RSV) in two different mouse strains: BALB/c and C57BL/6. We measured viral loads and analyzed differences in infection severity over time points of 3, 5, 9, 12, 21, 42, and 77 days post-inoculation. Significant findings (p<0.05) indicated notable differences in viral replication between RSV-infected and control groups across both strains, suggesting potential implications for therapeutic strategies in RSV infections.

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Comparative Analysis of RSV Infection in BALB/c and C57BL/6 Mice Models

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  1. ‡ # 4.0 Control BALB/c ‡ # Control C57BL/6 3.5 RSV BALB/c RSV C57BL/6 * p<0.05 C57BL/6 RSV infected mice vs C57BL/6 control ‡ p<0.05 BALB/c RSV infected mice vs BALB/c control # p<0.05 RSV BALB/c vs. RSV C57BL/6 n=4-16 mice per time point per group t-tests or Mann Whitney with Bonferroni correction 3.0 PFU/mL ‡ * 10 * 2.5 * Log 2.0 1 3 5 9 12 21 42 77 Days after RSV inoculation

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