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Syphilis

Syphilis . 制作人： 陈永　冯斌　时迎斌 张伟强　孙景福　 陈娜　徐平　周强　　 于晓宁　叶茜. 主讲人：叶茜. STD . AIDS. syphilis. syphilis. Ｃ．Ａ. Syphilis. There are more than 70,000 new cases of syphilis （梅毒） each year .

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Syphilis

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  1. Syphilis • 制作人： 陈永　冯斌　时迎斌 张伟强　孙景福　 陈娜　徐平　周强　　 于晓宁　叶茜 主讲人：叶茜

  2. STD AIDS syphilis syphilis Ｃ．Ａ

  3. Syphilis • There are more than 70,000 new cases of syphilis（梅毒） each year . • Syphilis, chronic and slowly progressive, is the third most common sexually transmitted disease.

  4. Spirochetes • Gram negative bacteria • long, thin, helical and motile • Axial filaments - (a form of flagella) - are the locomotory organelles • found between the peptidoglycan layer and • outer membrane and running parallel to them

  5. T.Pallidum

  6. Mechanism The antibodies result from tissue injury, with autoimmunity developing to self components.

  7. Transmission • T. pallidum is generally transmitted by • genital/genital contact. • Transmission in utero or during birth can also occur. It can also be transmitted through blood transfusion.

  8. Congenital syphilis

  9. Blood Transfusion • The main manifestation • Fever • Robeola • Symptoms like secondary stage of syphilis

  10. Pathogenic process • Primary syphilis • Secondary syphilis • Tertiary syphilis

  11. Primary syphilis • After initial infection hard chancre present. • Mainly seen in outer genital organ. • Last for 4 to 8 weeks.

  12. Secondary syphilis • The organisms has penetrate and systemically spread during this time period. • The patient has flu-like symptoms with secondary lesion particularly affecting the skin(2-10 weeks later) • Mainly in trunk and limbs.

  13. Secondary Syphilis

  14. Secondary Syphilis

  15. Common features of primary and secondary syphilis • In these two stages large numbers of T. Pallidum often present. • Strong infection , weak damage. • Self-limited

  16. Tertiary syphilis • The final stage is tertiary syphilis ( after several years later). • As the disease progresses immunity controls the bacterial replication and few organisms are seen. • Main manifestation are chronic granuloma and tissue necrosis.

  17. Tertiary Syphilis

  18. Tertiary Syphilis

  19. Diagnosis(1) • The organisms are often present in sufficient numbers in exudates detected by dark field microscopy. • The actively motile organisms appears brightly lit against the dark backdrop. • The FTA-ABS（荧光密螺旋体抗体吸收试验) is often used.

  20. Diagnosis(2) 3.VDRL and RPR are also widely used. • Serological methods are usually used to detect syphilis. 2. Screening methods are based on detecting serum antibodies to cardiolipin in patients (including VDRL test).

  21. Therapy • No vaccine exists, but antibiotic therapy (usually penicillin G) is usually highly effective.

  22. That is all . • Thank you!

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